Role of the ovarian cycle on neural cardiovascular control in sleep-deprived women.
Role of the ovarian cycle on neural cardiovascular control in sleep-deprived women.
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卵巢周期对睡眠不足女性神经心血管控制的作用。
DOI：
10.1152/japplphysiol.00626.2014
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Carter,JasonR
中科院分区：
文献类型：
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作者：
Yang,Huan;Durocher,JohnJ;Larson,RobertA;Carter,JasonR
与卵泡早期(EF)相比，卵巢周期的黄体中期(ML)通常是交感兴奋的。我们最近报道，24小时完全睡眠剥夺(TSD)会增强男性和女性的心血管反应性，但在静息肌肉交感神经活动(MSNA)对TSD的反应上存在性别差异。在目前的研究中，我们假设在睡眠剥夺的女性的ML阶段，静息MSNA增加，心血管对急性实验室应激源的反应性增强。对14例痛经妇女(年龄20±1岁)在仰卧位休息10min、精神应激(MS)5min、冷加压试验(CPT)2min的心率(HR)、平均动脉压(MAP)、前臂血管电导(FVC)和MSNA进行了测定。受试者在TSD后接受两次测试：一次在EF阶段，一次在ML阶段(随机、交叉设计)。雌二醇(29±2pg/mlvs.63±8pg/ml，P=0.001)和孕酮(1.6pg/mlvs.4.4±0.7pg/ml，P=0.002)明显升高。静息仰卧位MAP(75±2对72±1 mm Hg，P=0.042)在ML期较低。相比之下，EF期和ML期的静息HR、MSNA和FVC没有显著差异。EF期和ML期对MS的MAP、HR和FVC反应性差异无统计学意义。同样，MAP和HR对CPT的反应性在卵巢各时相之间也没有差异。与我们最初的假设相反，在缺乏睡眠的绝经前妇女中，ML期与交感神经兴奋或夸大的心血管反应无关。然而，我们的数据显示，睡眠不足的女性在EF期的静息血压升高。
The midluteal (ML) phase of the ovarian cycle is often sympathoexcitatory compared with the early follicular (EF) phase. We recently reported that 24-h total sleep deprivation (TSD) augmented cardiovascular reactivity in both men and women, but that sex differences existed in resting muscle sympathetic nerve activity (MSNA) responses to TSD. In the present study, we hypothesized increased resting MSNA and augmented cardiovascular reactivity to acute laboratory stressors during the ML phase in sleep-deprived women. Heart rate (HR), mean arterial pressure (MAP), forearm vascular conductance (FVC), and MSNA were measured in 14 eumenorrheic women (age, 20 ± 1 yr) during 10 min supine rest, 5 min mental stress (MS) trial, and 2 min cold pressor test (CPT) trial. Subjects were tested twice after TSD: once during EF phase and once during ML phase (randomized, crossover design). Estradiol (29 ± 2 vs. 63 ± 8 pg/ml,P= 0.001) and progesterone (1.6 ± 0.2 vs. 4.4 ± 0.7 ng/ml,P= 0.002) were elevated during the ML phase. Resting supine MAP (75 ± 2 vs. 72 ± 1 mmHg,P= 0.042) was lower during the ML phase. In contrast, resting supine HR, MSNA, and FVC were not significantly different between EF and ML phases. MAP, HR and FVC reactivity to MS were not statistically different between the EF and ML phases. Similarly, MAP and HR reactivity to CPT were not different between the ovarian phases. Contrary to our original hypothesis, the ML phase was not associated with sympathoexcitation or exaggerated cardiovascular reactivity in sleep-deprived premenopausal women. However, our data reveal elevated resting blood pressure during the EF phase in sleep-deprived women.