Skeletal PET with 18F-fluoride:: Applying new technology to an old tracer
Skeletal PET with 18F-fluoride:: Applying new technology to an old tracer
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DOI：
10.2967/jnumed.106.037200
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发表时间：
2008-01-01
影响因子：
9.3
通讯作者：
Treves, S. Ted
中科院分区：
文献类型：
--
作者：
Grant, Frederick D.;Fahey, Frederic H.;Treves, S. Ted
虽然F-18标记的NaF是第一个广泛使用的骨显像剂，但在引入Tc-99 m标记的骨显像剂后，它很快就被废弃了。最近的比较研究表明，F-18-氟化物PET比Tc-99 m-二膦酸盐SPECT更准确地识别骨骼的恶性和良性病变。将F-18-氟化物PET与其他影像学检查（如CT）相结合，可提高骨骼F-18-氟化物PET的特异性和总体准确性，并可能成为F-18-氟化物PET的常规临床实践。虽然F-18标记的NaF和Tc-99 m-二膦酸盐具有相似的患者剂量测定，但F-18-氟化物PET提供更短的研究时间（通常小于1小时），从而提高了工作流程的效率，改善了患者的便利性，并加快了向转诊医生提交报告的速度。随着PET扫描仪的广泛使用和F-18放射性药物输送物流的改善，F-18氟化物骨成像常规使用的局限性已在很大程度上被克服。与Tc-99 m-二膦酸盐骨显像相比，F-18-氟化物PET的良好成像性能和临床实用性支持重新考虑将F-18-氟化物作为常规骨显像剂。
Although F-18-labeled NaF was the first widely used agent for skeletal scintigraphy, it quickly fell into disuse after the introduction of Tc-99m-labeled bone-imaging agents. Recent comparative studies have demonstrated that F-18-fluoride PET is more accurate than Tc-99m-diphosphonate SPECT for identifying both malignant and benign lesions of the skeleton. Combining F-18-fluoride PET with other imaging, such as CT, can improve the specificity and overall accuracy of skeletal F-18-fluoride PET and probably will become the routine clinical practice for F-18-fluoride PET. Although F-18-labeled NaF and Tc-99m-diphosphonate have a similar patient dosimetry, F-18-fluoride PET offers shorter study times (typically less than 1 h), resulting in a more efficient workflow, improved patient convenience, and faster turnarounds of reports to the referring physicians. With the widespread availability of PET scanners and the improved logistics for the delivery of F-18 radiopharmaceuticals, prior limitations to the routine use of F-18-fluoride bone imaging have largely been overcome. The favorable imaging performance and the clinical utility of F-18-fluoride PET, compared with Tc-99m-diphosphonate scintigraphy, support the reconsideration of F-18-fluoride as a routine bone-imaging agent.