Change in marrow and spleen CFU compartments following leukemia virus infection: comparison of Friend and Rauscher virus.
Change in marrow and spleen CFU compartments following leukemia virus infection: comparison of Friend and Rauscher virus.
复制标题
白血病病毒感染后骨髓和脾脏 CFU 区室的变化：弗兰德病毒和 Rauscher 病毒的比较。
DOI：
10.1182/blood.v42.6.885.885
复制
发表时间：
1973
期刊：
影响因子：
20.3
通讯作者：
E. Phillips
中科院分区：
文献类型：
--
作者：
J. Okunewick;E. Phillips
研究了Friend和Rauscher白血病病毒对骨髓和脾集落形成单位隔室的影响。结果发现，这两种病毒产生的效果在质量上相似，但在数量上不同。比较单个病毒对脾脏和骨髓的影响也显示出显著差异。在脾中，在用任一病毒感染后14天，CFU隔室明显增大。在受感染小鼠的骨髓中，CFU数量与正常小鼠没有显著差异，而在Rauscher感染小鼠中，骨髓CFU下降了50%。F因子的测量结果表明，无论是病毒感染导致集落形成单位的缺陷相比，正常的能力，成功地“种子”在脾辐射正常受体，与更大的抑郁症的F因子被发现从脾组织中获得的细胞。这些结果表明，在这两种情况下，宿主组织（骨髓与脾脏）的性质对病毒作用的表达产生了显着的修饰作用，也表明多能集落形成单位可能是这些病毒的靶细胞。
The effects of the Friend and Rauscher leukemia viruses on the marrow and spleen colony-forming unit compartments have been studied. It was found that the two viruses produced qualitatively similar but quantitatively different effects relative to each other. Comparison of the effects of the individual virus on spleen with those on the marrow also showed striking differences. In the spleen by 14 days after infection with either virus the CFU compartment was grossly enlarged. In the marrow of the Friend-infected mouse the CFU number was not significantly different from normal, and in the Rauscher-infected mouse there was a 50% drop in marrow CFU. Measurement of the F factor showed that infection by either virus resulted in colony-forming units that were deficient as compared to the normal in their ability to successfully ''seed'' in the spleens of irradiated normal recipients, with the greater depression in F factor being found in cells obtained from spleen tissue. These results indicate that in both cases the nature of the host tissue (marrow versus spleen) exerts a significant modifying effect on the expression of the virus action, and also suggest that the pluripotent colony-forming unit may be a target cell for these viruses.