Experiment of in vivo imaging with third generation setup using Photon-Counting CT with 64ch Multi-Pixel Photon Counter
Experiment of in vivo imaging with third generation setup using Photon-Counting CT with 64ch Multi-Pixel Photon Counter
复制标题
使用带有 64 通道多像素光子计数器的光子计数 CT 进行第三代装置的体内成像实验
DOI：
10.1016/j.nima.2022.167580
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
S. Shiota
中科院分区：
文献类型：
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作者：
M. Sagisaka;T. Toyoda;J. Kataoka;M. Arimoto;H. Kawashima;S. Kobayashi;K. Murakami;K. Okumura;D. Sato;K. Yoshiura;T. Mizuno;K. Aiga;S. Terazawa;S. Shiota
X射线计算机层析成像是常用的诊断成像技术之一。然而，它也存在能量信息缺乏、高剂量暴露等问题。这些问题可以通过使用被称为光子计数CT(PC-CT)的下一代CT来解决。PC-CT能以极低的辐射剂量获得多色图像。我们提出的PC-CT探测器系统由多象素光子计数器(MPPC)和高速闪烁体组成，因此可以以较低的成本和较简单的系统制成。在这项研究中，我们提出了一种基于MPPC的PC-CT材料分解的新方法。此外，作为第一次尝试，我们使用基于MPPC的PC-CT系统对小鼠进行成像。在成像时注入碘和Gd混合造影剂和金纳米颗粒(AuNPs)。此外，小鼠的CT图像显示了骨骼、肺、心脏、肾脏和膀胱。作为未来的展望，我们将致力于可视化小鼠体内的药代动力学。
X-ray computed tomography is one of the commonly used diagnostic imaging technique. However, it has some problems which are lack of energy information and high dose exposure. These problems can be solved by using a next generation CT called Photon Counting CT (PC-CT). PC-CT can acquire multi-color images with significantly low radiation dose. The detector system of the PC-CT we propose consists of Multi-Pixel Photon Counter (MPPC) coupled with a high-speed scintillator thus can be made with lower cost and simpler system. In this study, we propose a novel method of material decomposition using the MPPC based PC-CT. Furthermore, we imaged mice with MPPC based PC-CT system as a first attempt. Iodine and gadolinium mixed contrast agents and gold-nanoparticles (AuNPs) were injected when imaging. In addition, the CT images of mice showed bone, lungs, heart, kidneys, and bladder. As a future prospect, we will work on visualizing the pharmacokinetics in mice.