Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
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DOI：
10.1056/nejmoa022152
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发表时间：
2002-10-17
影响因子：
158.5
通讯作者：
Wolmark, N
中科院分区：
文献类型：
--
作者：
Fisher, B;Anderson, S;Wolmark, N
背景资料：在1976年，我们开始了一项随机试验，以确定是否有或没有放射治疗的肿块切除术是有效的全乳房切除术治疗浸润性breastcancer.Methods：共1851名妇女的随访数据和淋巴结的状态是已知的随机分配的治疗组成的全乳房切除术，肿块切除术，或肿块切除术和乳房照射。结果：行乳腺肿瘤切除术并放疗的患者同侧乳腺肿瘤复发的累积发生率为14.3%，而行乳腺肿瘤切除术而不放疗的患者为39.2%（P
Background: In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer.Methods: A total of 1851 women for whom follow-up data were available and nodal status was known underwent randomly assigned treatment consisting of total mastectomy, lumpectomy alone, or lumpectomy and breast irradiation. Kaplan-Meier and cumulative-incidence estimates of the outcome were obtained.Results: The cumulative incidence of recurrent tumor in the ipsilateral breast was 14.3 percent in the women who underwent lumpectomy and breast irradiation, as compared with 39.2 percent in the women who underwent lumpectomy without irradiation (P