THE PRESENCE OF FREE D-ASPARTIC ACID IN RODENTS AND MAN
THE PRESENCE OF FREE D-ASPARTIC ACID IN RODENTS AND MAN
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DOI：
10.1016/s0006-291x(86)80329-1
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发表时间：
1986-11-26
影响因子：
3.1
通讯作者：
LAJTHA, A
中科院分区：
文献类型：
--
作者：
DUNLOP, DS;NEIDLE, A;LAJTHA, A
游离d -天冬氨酸在啮齿类动物的大脑和其他组织以及人类血液中存在相当数量。在新生大鼠的大脑半球中，d -天冬氨酸的浓度最高，达到164 nmol/g（占总天冬氨酸的8.4%），超过了许多必需的l -氨基酸的水平。D-与总天冬氨酸的比例最高（38%）发生在新生儿血细胞中。在成年大鼠中，垂体中浓度最高（127 nmol/g, 3.8%）。在中枢神经系统内，存在显著的区域差异，并随着发育发生特征性变化。一般来说，d -天冬氨酸水平随着年龄的增长而迅速下降。在大脑半球，在一周内接近成人值（13 nmol/g, 0.43%）。d -天冬氨酸在年轻人中的浓度也可能更高，因为取自胎盘脐带的胎儿血液中含有2.6纳摩尔/克（4.9%）的d -天冬氨酸，是成人血液中d -天冬氨酸的5倍。这些分布模式和发育变化可能是不同组织处理外来代谢物能力差异的结果，或者反映了d -天冬氨酸特定功能需求的改变。
Free D-aspartic acid is present in appreciable quantities in the brain and other tissues of rodents and in human blood. In the newborn rat, the highest concentration of D-aspartic acid was found in cerebral hemispheres, where, at 164 nmol/g (8.4% of the total aspartic acid), the level of D-aspartic acid exceeds that of many essential L-amino acids. The highest ratio of D- to total aspartic acid (38%) occurred in neonatal blood cells. In the adult rat, the highest concentration was present in the pituitary gland (127 nmol/g, 3.8%). Within the central nervous system marked regional differences are present and characteristic changes with development take place. In general, the levels of D-aspartic acid fall rapidly with increasing age. In cerebral hemispheres adult values (13 nmol/g, 0.43%) are approached within one week. D-aspartic acid concentrations may also be higher in young humans since fetal blood, taken from placental cord, contains 2.6 nmol/g (4.9%) of D-aspartic acid, a value five times that of adult human blood. These distributional patterns and developmental changes may be the result of differences in the ability of various tissues to dispose of an extraneous metabolites, or, reflect alterations in a specific functional requirement for D-aspartic acid.