Role of the gastrointestinal tract in burn sepsis
Role of the gastrointestinal tract in burn sepsis
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DOI：
10.1097/01.bcr.0000150212.21651.79
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Gamelli, RL
中科院分区：
文献类型：
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作者：
Gosain, A;Gamelli, RL
在过去的50年中，我们对胃肠道作为预防烧伤后败血症发生的第一道防线的作用的认识有了极大提高。从肠道细菌会导致远处损伤这一概念开始，研究人员已经描绘出胃肠道屏障一系列复杂的生理变化。随着对这些生理变化的了解，人们也认识到免疫系统在调节烧伤后器官衰竭中的作用。重要的是，近期对肠系膜淋巴作用的研究从根本上改变了器官衰竭的模式，并表明肠道是一个分泌细胞因子的器官。本文追溯了烧伤败血症研究中关键概念的发展及其临床意义。
During the last 50 years, our understanding of the role of the gastrointestinal tract as a first-line defense against the development of postburn sepsis has increased dramatically. Starting with the concept of that gut-derived bacteria cause distant injury, investigators have delineated a complex series of physical changes in the barrier of the gastrointestinal tract. Along with an understanding of these physical changes has come an appreciation of the role of the immune system in modulating postburn organ failure. Importantly, recent investigations into the role of mesenteric lymph have fundamentally changed the paradigm of organ failure and have implicated the gut as a cytokine-secreting organ. This article traces the development of key concepts in the study of burn sepsis and their clinical implications.