Brain structures involved in interoceptive awareness and cardioafferent signal processing: A dipole source localization study
Brain structures involved in interoceptive awareness and cardioafferent signal processing: A dipole source localization study
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DOI：
10.1002/hbm.20121
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发表时间：
2005-09-01
影响因子：
4.8
通讯作者：
Schandry, R
中科院分区：
文献类型：
--
作者：
Pollatos, O;Kirsch, W;Schandry, R
来自身体的传入信号在行为的情感和动机方面发挥着重要作用。然而，对参与感觉间过程的皮质和皮质下结构知之甚少。最近，一项功能磁共振研究表明，当受试者将注意力集中在他们的心跳上时，脑岛、躯体运动和扣带皮质被激活。除了使用成像数据外，人们还经常使用心跳诱发电位(HEP)来研究心脏意识，HEP是一种似乎取决于心跳的脑波。本研究旨在定位HEP的来源。44名受试者在完成心跳感知任务时被记录了多道脑电。这项任务被用来量化相互感觉意识，并将受试者细分为良好和不良心跳知觉者。分析显示，在R波开始后200ms的时间范围内，额部和额部-中央电极位置的HEP波幅最高。通过BESA偶极子源分析，确定了HEP的四个来源，分别位于前扣带回、右侧脑岛、前额叶皮质和左侧次级躯体感觉皮质。在所有四种大脑皮层来源中，心跳良好的受试者表现出显著高于心跳不良受试者的HEP幅度和偶极子强度。我们的结论是，所识别的结构参与了心脏信号的处理，因此前扣带回和右脑岛似乎是心脏感觉的内感中枢。
Afferent signals from the body play an important role for emotional and motivational aspects of behavior. Nevertheless, little is known about the cortical and subcortical structures involved in interoceptive processes. Recently, a functional MRI study demonstrated that insula, somatomotor, and cingulated cortices are activated when subjects focus attention on their heartbeats. Aside from the use of imaging data, cardiac awareness has frequently been studied by using the heartbeat-evoked potential (HEP), a brain wave that appears contingent on the heartbeat. The present study aimed at localizing sources of the HEP. Multichannel EEG was recorded in 44 subjects while they performed a heartbeat perception task. This task was used to quantify interoceptive awareness and to subdivide the subjects into good and poor heartbeat perceivers. Analyses showed highest HEP amplitudes over frontal and fronto-central electrode locations in the time range of later than 200 ms after R-wave onset. By means of a BESA dipole-source-analysis, four sources of the HEP were identified which were located in the anterior cingulate, the right insula, the prefrontal cortex, and the left secondary somatosensory cortex. Good heartbeat perceivers showed both significantly higher HEP amplitudes and higher dipole strength than poor heartbeat perceivers in all four cortical sources. We conclude that the identified structures are involved in the processing of cardiac signals, whereby anterior cingulate and right insula seem to serve as interoceptive centers for cardioception.