Efficient Synthesis of Heterocyclic Neurotensin Receptor Ligands by Microwave-Assisted Aminocarbonylation
Efficient Synthesis of Heterocyclic Neurotensin Receptor Ligands by Microwave-Assisted Aminocarbonylation
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微波辅助氨基羰基化高效合成杂环神经降压素受体配体
DOI：
10.1055/s-0033-1338497
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
C. Lang P. Gmeiner
中科院分区：
文献类型：
--
作者：
C. Lang P. Gmeiner
据报道，以杂环神经降压素受体拮抗剂SR142948A为先导化合物，开发了一种有效且实用的杂环芳基甲酰胺合成路线。因此，利用 Mo(CO)6、Herrmann’s palladacycle、[(t-Bu)3PH]BF4 和 DBU 介导的微波辅助氨基羰基化反应，精心设计了高效、灵活地获取这些甲酰胺的方法。
Marking the heterocyclic neurotensin receptor antagonist SR142948A as a lead compound, the development of an efficient and a practical synthetic route to heterocyclic aryl carboxamides is reported. Thus, a highly efficient and flexible access to these carboxamides was elaborated by taking advantage of microwave-assisted aminocarbonylation reaction mediated by Mo(CO)6, Herrmann’s palladacycle, [(t-Bu)3PH]BF4, and DBU.