Articulatory rehearsal in verbal working memory: A possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder
Articulatory rehearsal in verbal working memory: A possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder
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DOI：
10.1016/j.neulet.2006.06.062
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发表时间：
2006-09-11
影响因子：
2.5
通讯作者：
Falkai, Peter
中科院分区：
文献类型：
--
作者：
Gruber, Oliver;Gruber, Eva;Falkai, Peter
最近的功能磁共振研究已经确定了健康人工作记忆的不同组成部分背后的大脑系统。这项研究的目的是比较这些神经网络在精神分裂症、分裂情感障碍患者和健康对照组的行为表现方面的功能完整性。为了根据潜在大脑回路的功能障碍来检测特定的工作记忆缺陷，我们使用了与之前的神经成像研究中相同的语言和视觉空间Sternberg项目识别任务。对由14名受试者组成的匹配组的临床和表现数据进行统计分析。精神分裂症患者表现出明显的言语和视觉空间工作记忆障碍，而分裂情感患者的言语工作记忆表现得到保留。这些发现提供了第一个证据，表明辅助发音排练的大脑系统功能障碍可能是区分精神分裂症和分裂情感障碍的生物标志。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Recent fMRI studies have identified brain systems underlying different components of working memory in healthy individuals. The aim of this study was to compare the functional integrity of these neural networks in terms of behavioural performance in patients with schizophrenia, schizoaffective disorder and healthy controls. In order to detect specific working memory deficits based on dysfunctions of underlying brain circuits we used the same verbal and visuospatial Sternberg item-recognition tasks as in previous neuroimaging studies. Clinical and performance data from matched groups consisting of 14 subjects each were statistically analyzed. Schizophrenic patients exhibited pronounced impairments of both verbal and visuospatial working memory, whereas verbal working memory performance was preserved in schizoaffective patients. The findings provide first evidence that dysfunction of a brain system subserving articulatory rehearsal could represent a biological marker which differentiates between schizophrenia and schizoaffective disorder. (c) 2006 Elsevier Ireland Ltd. All rights reserved.