Granulocyte‐Specific Antinuclear Antibodies

Granulocyte‐Specific Antinuclear Antibodies
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粒细胞特异性抗核抗体

DOI:
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发表时间:
1980
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影响因子:
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通讯作者:
A. Wilk
A. Wilk
中科院分区:
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文献类型:
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作者:
A. Wilk

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出版商摘要 本章重点介绍粒细胞特异性抗核抗体(GS-ANA)。类风湿性关节炎和弗氏综合征中的GS-ANA主要是G型免疫球蛋白抗体,具有参与循环和滑液免疫复合物的倾向-这些在类风湿性滑膜中局部产生,表明与发病机制的关系。一些证据表明GS-ANA在发病机制中的作用,例如在活动性疾病中发现的较高患病率和水平以及GS-ANA在局部和循环免疫复合物中的存在。
Publisher Summary This chapter focuses on granulocyte-specific antinuclear antibodies (GS-ANA). GS-ANA in rheumatoid arthritis and Felty's syndrome are mainly type G immunoglobulin antibodies with a tendency to engage in circulating and synovial fluid immune complexes––these are produced locally in the rheumatoid synovium indicating a relationship to pathogenesis. Some evidences suggest role for GS-ANA in pathogenesis, such as the higher prevalence and levels found in active disease and the presence of GS-ANA in local and circulating immune complexes.