ANASTOMOTIC SUTURE MATERIALS AND EXPERIMENTAL COLORECTAL CARCINOGENESIS
ANASTOMOTIC SUTURE MATERIALS AND EXPERIMENTAL COLORECTAL CARCINOGENESIS
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DOI：
10.1007/bf02049962
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发表时间：
1991-11-01
影响因子：
3.9
通讯作者：
GEORGE, WD
中科院分区：
文献类型：
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作者：
MCGREGOR, JR;GALLOWAY, DJ;GEORGE, WD
结直肠癌恢复性手术后局部肿瘤复发有时可能是由于吻合口附近增生性不稳定区肿瘤病变的促进。本研究的目的是在实验动物模型中比较三种吻合缝线材料，包括不锈钢（作为手术缝合模型）对结直肠癌发生的影响。在肿瘤诱导起始后阶段，在白化瑞士大鼠的远端降结肠中经壁植入不锈钢线，与聚酰胺（Nurolon(R)）相比，12周后出现吻合口周围肿瘤的动物明显减少（21只动物中的3只）；Ethicon, Edinburgh, uk) （14 / 20, P < 0.001）或聚乙醇酸(Dexon Plus(R)；Davis和Geck， Gosport，英国)缝合（21只动物中有17只；P < 0.001）。当使用相同的材料重新缝合纵向结肠切开术时，结果相似。在这两种手术中，缝合材料的类型对远离吻合部位的大肠肿瘤的发生率没有影响。这些结果表明，与某些更传统的缝合材料相比，不锈钢钉可能更少地促进吻合口周围大肠肿瘤的发生，因此可以安全地用于结直肠癌手术。
Local tumor recurrence following restorative surgery for colorectal cancer may occasionally result from the promotion of a neoplastic lesion in a zone of proliferative instability adjacent to the anastomosis. The aim of this study was to compare the influence of three anastomotic suture materials, including stainless steel (as a model of surgical stapling), on colorectal carcinogenesis in an experimental animal model. The transmural implantation of stainless steel sutures into the distal descending colon of albino Swiss rats during the postinitiation phase of tumor induction resulted in significantly fewer animals exhibiting perianastomotic tumors 12 weeks later (3 of 21 animals) when compared with either polyamide (Nurolon(R); Ethicon, Edinburgh, United Kingdom) (14 of 20 animals; P < 0.001) or polyglycolic acid (Dexon Plus(R); Davis and Geck, Gosport, United Kingdom) sutures (17 of 21 animals; P < 0.001). The findings were similar when the same materials were used to resuture a longitudinal colotomy. For both operative procedures, the type of suture material had no influence on the incidence of large bowel tumors distant from the anastomotic site. These results suggest that stainless steel staples may promote fewer perianastomotic large bowel tumors than certain more conventional suture materials and, therefore, may be safely employed in colorectal cancer surgery.