Association between peripheral γδ T-cell profile and disease progression in individuals infected with HIV-1 or HIV-2 in West Africa.
Association between peripheral γδ T-cell profile and disease progression in individuals infected with HIV-1 or HIV-2 in West Africa.
复制标题
DOI：
10.1097/qai.0b013e318215a877
复制
发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Kiviat NB
中科院分区：
文献类型：
--
作者：
Zheng NN;McElrath MJ;Sow PS;Mesher A;Hawes SE;Stern J;Gottlieb GS;De Rosa SC;Kiviat NB
Human gammadelta (γδ) T cells play an important role in protective immunity in HIV-1 and SIV infection; their role in HIV-2 infection is unknown. To determine the role of γδ T cells in control of plasma viral load and CD4+ T-cell count in HIV-1 and HIV-2 infections in West Africa. Thirty HIV-1 and 25 HIV-2 treatment-naïve chronically infected individuals, as well as 20 HIV-seronegative individuals from Senegal were studied using multi-parametric flow cytometry to investigate the frequencies and phenotypes of peripheral γδ T-cells. γδ T-cells parameters and correlates of HIV disease progression were assessed. We observed an expansion of Vδ1+ T-cell populations in both HIV-1 and HIV-2 infection. However, unlike HIV-1 infection, no significant contraction of the frequency of total Vδ2+ T cells was observed in HIV-2 infection. Significantly lower frequencies of CD4+Vδ2+ T cells were observed in HIV-2 infected individuals. Furthermore, frequencies of CD28−CD45RO+ and CD27−CD28−CD45RO− Vδ2+ T-cell were low in HIV-1 infected individuals. Vδ2+ T-cell activation levels were elevated in both HIV-1 and HIV-2 infected individuals. The frequency of HLA-DR−CD38+ activated Vδ1+ and Vδ2+ T-cells was associated with a decline in CD4+ T-cell counts and increased viral load in both HIV-1 and HIV-2 infection. While maintaining the normal frequency of total Vδ2+ T cells, HIV-2 infection reduces the frequency of CD4+Vδ2+ T cells and alters the frequencies of subsets of Vδ1+ T cells. Both HIV-1 and HIV-2 infection induce γδ T cell activation, and this activation is associated with the disease progression.
