Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.
Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.
复制标题
检测体内分枝杆菌的毒力和耐药表型。
DOI：
10.1016/j.tim.2015.02.013
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发表时间：
2015
影响因子：
15.9
通讯作者：
Timmins,GrahamS
中科院分区：
文献类型：
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作者：
Timmins,GrahamS
细菌表型主要在培养物中进行研究，因为检测它们在宿主中的特定代谢途径具有挑战性。稳定同位素呼气测试的发展，可以进行原位表型分析，可以为基于直接监测体内微生物代谢和宿主-病原体表型相互作用的诊断提供新的模式。
Bacterial phenotypes are predominantly studied in culture because detection of their specific metabolic pathways in the host is challenging. Development of stable-isotope breath tests, allowing in situ phenotype analyses, may endow diagnostics with new modalities based upon direct monitoring of in vivo microbial metabolism and host–pathogen phenotypic interactions.