Rehearsal initiates systems memory consolidation, sleep makes it last
Rehearsal initiates systems memory consolidation, sleep makes it last
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DOI：
10.1126/sciadv.aav1695
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发表时间：
2019-04-01
期刊：
影响因子：
13.6
通讯作者：
Gais, S.
中科院分区：
文献类型：
--
作者：
Himmer, L.;Schoenauer, M.;Gais, S.
在编码之后，存储器经历一个称为系统存储器合并的过渡过程。它允许海马体快速获取新信息，并在新皮质长期网络中稳定存储，在那里记忆受到保护，不受干扰。虽然这个过程通常被认为随着时间和睡眠的推移而缓慢发生，但我们最近发现，记忆系统从海马体到后顶叶皮质(PPC)的快速转换发生在一个研究阶段的重复排练中。在这里，我们使用功能磁共振成像来证明，这种转变在睡眠中稳定下来，而清醒状态会导致重置到幼稚的反应，比如在早期编码期间观察到的反应。因此，睡眠的作用似乎超越了先前所认为的通过记忆轨迹重新激活来提供额外的排练。我们的结论是，反复学习会导致系统整合，而睡眠则确保这些转换变得稳定和持久。因此，睡眠和反复排练共同促进了长期记忆的巩固。
After encoding, memories undergo a transitional process termed systems memory consolidation. It allows fast acquisition of new information by the hippocampus, as well as stable storage in neocortical long-term networks, where memory is protected from interference. Whereas this process is generally thought to occur slowly over time and sleep, we recently found a rapid memory systems transition from hippocampus to posterior parietal cortex (PPC) that occurs over repeated rehearsal within one study session. Here, we use fMRI to demonstrate that this transition is stabilized over sleep, whereas wakefulness leads to a reset to naive responses, such as observed during early encoding. The role of sleep therefore seems to go beyond providing additional rehearsal through memory trace reactivation, as previously thought. We conclude that repeated study induces systems consolidation, while sleep ensures that these transformations become stable and long lasting. Thus, sleep and repeated rehearsal jointly contribute to long-term memory consolidation.