β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor.
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor.
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DOI：
10.1016/j.celrep.2018.01.041
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发表时间：
2018-02-06
期刊：
影响因子：
8.8
通讯作者：
Bonewald LF
中科院分区：
文献类型：
--
作者：
Kitase Y;Vallejo JA;Gutheil W;Vemula H;Jähn K;Yi J;Zhou J;Brotto M;Bonewald LF
运动对新陈代谢和组织都有好处。运动诱导肌肉因子β-氨基异丁酸（BAIBA）在白色脂肪褐变和胰岛素抵抗中起关键作用。在这里，我们展示了白芭的另一种功能，即骨骼保护因子，可防止活性氧（ROS）诱导的骨细胞死亡。与雌激素或n-乙酰半胱氨酸相比，L-BAIBA具有同等或更强的保护作用，可通过mass相关G蛋白偶联受体D型（MRGPRD）发出信号，阻止ROS引起的线粒体破坏。在小鼠后肢卸荷模型（骨细胞凋亡模型）中，饮水中添加白芭可防止骨丢失和肌肉功能丧失。白芭的保护作用随着年龄的增长而丧失，不是由于肌肉产生白芭的能力丧失，而是可能随着年龄的增长而减少Mrgprd的表达。这对于理解运动对骨骼随着年龄增长而减弱的影响具有启示意义。
Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). L-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.
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