PAM50: Unbiased multimodal template of the brainstem and spinal cord aligned with the ICBM152 space
PAM50: Unbiased multimodal template of the brainstem and spinal cord aligned with the ICBM152 space
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DOI：
10.1016/j.neuroimage.2017.10.041
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发表时间：
2018-01-15
期刊：
影响因子：
5.7
通讯作者：
Cohen-Adad, Julien
中科院分区：
文献类型：
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作者：
De Leener, Benjamin;Fonov, Vladimir S.;Cohen-Adad, Julien
基于模板的脊髓多参数MRI数据分析为标准化和可重复性奠定了基础，从而有助于发现新的脊柱相关疾病的生物标志物。虽然最近引入了脊髓的MRI模板，但它们都没有覆盖整个脊髓。在这项研究中，我们引入了一个无偏的脊髓和脑干的多模态MRI模板，称为PAM50，它与ICBM152脑模板在解剖学上是兼容的，并使用相同的坐标系。PAM50模板基于50名健康受试者，覆盖整个脊髓（C1至L2椎体水平）和脑干，可用于T1， T2和T2*加权MRI对比，并包括灰质和白质束的概率图谱。通过计算注册到模板后每个脊髓中心线与PAM50中心线之间的平均和最大距离误差来评估模板创建的准确性。结果显示T1-（平均值= 0.37 +/- 0.06 mm，最大值= 1.39 +/- 0.58 mm）和t2 -加权（平均值= 0.11 +/- 0.03 mm，最大值= 0.71 +/- 0.27 mm）对比具有较高的准确性。此外，在模板创建过程中，通过比较所有受试者的平均横断面积（CSA）剖面和PAM50模板的CSA剖面，验证了脊髓拓扑结构的保存。PAM50和ICBM152模板的融合将促进脑脊髓联合MRI的分组和多中心研究，并使现有脑干地图集的使用与ICBM空间兼容。
Template-based analysis of multi-parametric MRI data of the spinal cord sets the foundation for standardization and reproducibility, thereby helping the discovery of new biomarkers of spinal-related diseases. While MRI templates of the spinal cord have been recently introduced, none of them cover the entire spinal cord. In this study, we introduced an unbiased multimodal MRI template of the spinal cord and the brainstem, called PAM50, which is anatomically compatible with the ICBM152 brain template and uses the same coordinate system. The PAM50 template is based on 50 healthy subjects, covers the full spinal cord (C1 to L2 vertebral levels) and the brainstem, is available for T1-, T2-and T2*-weighted MRI contrasts and includes a probabilistic atlas of the gray matter and white matter tracts. Template creation accuracy was assessed by computing the mean and maximum distance error between each individual spinal cord centerline and the PAM50 centerline, after registration to the template. Results showed high accuracy for both T1-(mean = 0.37 +/- 0.06 mm; max = 1.39 +/- 0.58 mm) and T2-weighted (mean = 0.11 +/- 0.03 mm; max = 0.71 +/- 0.27 mm) contrasts. Additionally, the preservation of the spinal cord topology during the template creation process was verified by comparing the cross-sectional area (CSA) profile, averaged over all subjects, and the CSA profile of the PAM50 template. The fusion of the PAM50 and ICBM152 templates will facilitate group and multi-center studies of combined brain and spinal cord MRI, and enable the use of existing atlases of the brainstem compatible with the ICBM space.