The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis
The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis
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DOI：
10.1073/pnas.93.5.1924
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发表时间：
1996-03-05
影响因子：
11.1
通讯作者：
Pinder, A
中科院分区：
文献类型：
--
作者：
Brown, DD;Wang, Z;Pinder, A
非洲爪哇尾巴吸收程序中受甲状腺激素上调和下调的基因已经通过基因表达筛选分离、测序，并在GenBank数据库中进行了鉴定，整个程序估计由不到35个上调基因和不到10个下调基因组成；其中分别有17个和4个基因已经被分离和鉴定，根据它们的序列可以预测其功能的上调基因包括四个转录因子(包括一个甲状腺激素受体)，一个细胞外基质成分(纤维连接蛋白)和膜受体(整合素)，四个蛋白酶，一个降解甲状腺激素的脱碘酶，以及一个结合下丘脑促肾上腺皮质激素释放因子的蛋白，这四个下调的基因都编码在蝌蚪表皮中表达的细胞外蛋白。
Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base, The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; 17 and 4 of them, respectively, have been isolated and characterized, Up-regulated genes whose function can be predicted on the basis of their sequence include four transcription factors (including one of the thyroid hormone receptors), an extracellular matrix component (fibronectin) and membrane receptor (integrin), four proteinases, a deiodinase that degrades thyroid hormone, and a protein that binds the hypothalamic corticotropin-releasing factor, which has been Implicated in controlling thyroid hormone synthesis in Xenopus tadpoles, All four down-regulated genes encode extracellular proteins that are expressed in tadpole epidermis, This survey of the program provides insights Into the biology of metamorphosis.