Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type.
Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type.
复制标题
阿尔茨海默型老年痴呆患者血糖和胰岛素分泌的变化。
作者：
G. Bucht;R. Adolfsson;F. Lithner;B. Winblad
回顾性分析了839例诊断为各种痴呆的医院记录，其中63例同时诊断为糖尿病。在阿尔茨海默型老年痴呆（SDAT）患者组中没有发现这些。分别对SDAT、多发性脑梗死性痴呆（MID）、脑血管病（CVD）、住院对照患者（Chosp）和健康老年人（Celd）进行口服糖耐量试验（OGTT）。与CVD组和Chosp组相比，SDAT组空腹血糖明显降低，OGTT曲线下面积明显减小。在OGTT期间，SDAT患者的胰岛素水平高于Celd，并且在摄入糖后90分钟的水平具有统计学意义。我们的研究结果表明，SDAT和糖尿病可能并不共存，SDAT患者的血糖浓度降低，血清胰岛素水平升高。本文讨论了这是否是SDAT中发射机缺陷的影响，还是可以用来解释这些缺陷。
A retrospective study of 839 hospital records with various dementia diagnoses showed that 63 cases had a diagnosis of diabetes mellitus as well. None of these were found in the group of patients with senile dementia of Alzheimer type (SDAT). Oral glucose tolerance tests (OGTT) were performed in patients with SDAT, multiinfarct dementia (MID), cerebrovascular disease (CVD), hospitalized control patients (Chosp) and healthy elderly persons (Celd). Fasting blood sugar was significantly lower and the areas under the OGTT curves were significantly smaller in the SDAT group than in the CVD and the Chosp group. SDAT patients had higher insulin levels than Celd during the OGTT and on a statistically significant level 90 min after ingestion of sugar. Our findings suggest that SDAT and diabetes mellitus may not co-exist and that patients with SDAT have decreased blood sugar concentrations and elevated serum insulin levels. It is discussed whether this is an effect of the transmitter deficiencies in SDAT or may serve to explain these deficiencies.