Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors
Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors
复制标题
DOI：
10.1016/j.dib.2016.06.018
复制
发表时间：
2016-09-01
期刊：
影响因子：
1.2
通讯作者：
Antonelou, Marianna H.
中科院分区：
文献类型：
--
作者：
Tzounakas, Vassilis L.;Kriebardis, Anastasios G.;Antonelou, Marianna H.
本文包含了合格的葡萄糖-6磷酸脱氢酶（G6 PD）缺乏的供体捐献的红细胞（RBC）在标准血库条件下储存期间与对照G6 PD充足（G6 PD（+））细胞相比的几个生理参数变化的数据。在37 ℃下孵育储存细胞24 h后，在整个储存期间，在有或没有氧化剂刺激、补充N-乙酰半胱氨酸和能量消耗的情况下，测量RBC中细胞内活性氧（ROS）的产生、细胞脆性和膜外囊泡形成。除了细胞特性，总的或尿酸依赖性的抗氧化能力的上清液，除了细胞外钾浓度测定在RBC单位。最后，在微粒群中测量促凝血活性和蛋白质羰基化水平。进一步的信息可以在“葡萄糖6-磷酸脱氢酶缺乏的受试者可能比红细胞供体更好“储存”中找到[1]。(C)2015作者爱思唯尔公司出版这是CC BY许可证下的开放获取文章（http：//creativecommons.org/licenses/by/40）。
This article contains data on the variation in several physiological parameters of red blood cells (RBCs) donated by eligible glucose-6 phosphate dehydrogenase (G6PD) deficient donors during storage in standard blood bank conditions compared to control, G6PD sufficient (G6PD(+)) cells. Intracellular reactive oxygen species (ROS) generation, cell fragility and membrane exovesiculation were measured in RBCs throughout the storage period, with or without stimulation by oxidants, supplementation of N-acetylcysteine and energy depletion, following incubation of stored cells for 24 h at 37 degrees C. Apart from cell characteristics, the total or uric acid-dependent antioxidant capacity of the supernatant in addition to extracellular potassium concentration was determined in RBC units. Finally, procoagulant activity and protein carbonylation levels were measured in the microparticles population. Further information can be found in "Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells" [1]. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/40).