Effect of vertebral, carotid and intravenous infusions of lysine vasopressin on plasma vasopressin and cardiovascular function.
Effect of vertebral, carotid and intravenous infusions of lysine vasopressin on plasma vasopressin and cardiovascular function.
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椎体、颈动脉和静脉输注赖氨酸加压素对血浆加压素和心血管功能的影响。
DOI：
10.1159/000124003
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发表时间：
1984
影响因子：
4.1
通讯作者：
Rockhold,RW
中科院分区：
文献类型：
--
作者：
Brooks,DP;Share,L;Crofton,J;Matsui,K;Rockhold,RW
椎动脉、颈动脉和静脉的心血管和加压素释放作用。对麻醉犬静脉注射赖氨酸加压素(150µU/kg·min)进行了研究。椎动脉和颈动脉注射赖氨酸加压素导致的心输出量下降与静脉注射相似。输液。然而，与静脉注射赖氨酸加压素相比，椎动脉和颈动脉注射赖氨酸加压素的心率下降幅度更大。输液。平均动脉压和血浆加压素浓度均无变化。结果表明，外周血管加压素：(1)具有减慢心率的中枢作用；(2)对心脏有外周作用，减少心输出量；(3)可能不反馈抑制自身释放。
The cardiovascular and vasopressin-releasing effects of vertebral artery, carotid artery and intravenous (i.v.) infusions of lysine vasopressin (150 µU/kg·min) were studied in anesthetized dogs. Vertebral and carotid artery infusions of lysine vasopressin led to similar decreases in cardiac output as i.v. infusions. Heart rate, however, decreased to a greater extent with vertebral and carotid artery infusions of lysine vasopressin than i.v. infusions. There were no changes in either mean arterial blood pressure or the plasma vasopressin concentration. The results indicate that peripheral vasopressin: (1 has a central effect to reduce heart rate; (2) has a peripheral effect on the heart to reduce cardiac output, and (3) probably does not feed back to inhibit its own release.