Optimization of cardiac fiber orientation for homogeneous fiber strain during ejection
Optimization of cardiac fiber orientation for homogeneous fiber strain during ejection
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DOI：
10.1114/1.147
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发表时间：
1999-05-01
影响因子：
3.8
通讯作者：
Arts, T
中科院分区：
文献类型：
--
作者：
Rijcken, J;Bovendeerd, PHM;Arts, T
在心动周期的射血期间，心脏中的肌纤维的应变可能均匀地分布在心壁上。左心室（LV）壁力学的数学模型表明，在射血过程中的纤维应变分布是敏感的壁中的肌纤维的方向。在目前的研究中，我们测试的假设，在左心室壁的纤维取向是这样的，在喷射过程中的纤维应变是尽可能均匀的。建立了左心室壁力学的有限元模型，以计算相对于舒张中期参考状态，在心动周期射血期开始（BE）和结束（EE）时的纤维应变分布。通过三个参数量化的LV壁的纤维取向的分布，系统地变化，以尽量减少区域差异，在喷射过程中的纤维缩短，并在BE和EE的纤维应变的平均值。一个定义明确的最佳的纤维取向的分布被发现，这是没有显着不同的解剖测量。优化后，BE和EE时纤维应变的平均值为0.025 +/-0.011（平均值+/-标准差），射出期间纤维应变的差异为0.214+/-0.018。结果表明，LV结构的设计是为了在弹射过程中最大限度地均匀纤维应变。(C)1999年生物医学工程学会。[S0090-6964（99）01603-3]。
The strain of muscle fibers in the heart is likely to be distributed uniformly over the cardiac walls during the ejection period of the cardiac cycle. Mathematical models of left ventricular (LV) wall mechanics have shown that the distribution of fiber strain during ejection is sensitive to the orientation of muscle fibers in the wall. In the present study, we tested the hypothesis that fiber orientation in the LV wall is such that fiber strain during ejection is as homogeneous as possible. A finite-element model of LV wall mechanics was set up to compute the distribution of fiber strain at the beginning (BE) and end (EE) of the ejection period of the cardiac cycle, with respect to a middiastolic reference state. The distribution of fiber orientation over the LV wall, quantified by three parameters, was systematically varied to minimize regional differences in fiber shortening during ejection and in the average of fiber strain at BE and EE. A well-defined optimum in the distribution of fiber orientation was found which was not significantly different from anatomical measurements. After optimization, the average of fiber strain at BE and EE was 0.025 +/-0.011 (mean+/-standard deviation) and the difference in fiber strain during ejection was 0.214+/-0.018. The results indicate that the LV structure is designed for maximum homogeneity of fiber strain during ejection. (C) 1999 Biomedical Engineering Society. [S0090-6964(99)01603-3].