Behavioral and Cortical Correlates of Self-Suppression, Anticipation, and Ambivalence in Rat Tickling
Behavioral and Cortical Correlates of Self-Suppression, Anticipation, and Ambivalence in Rat Tickling
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DOI：
10.1016/j.cub.2019.07.085
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发表时间：
2019-10-07
期刊：
影响因子：
9.2
通讯作者：
Brecht, Michael
中科院分区：
文献类型：
--
作者：
Ishiyama, Shimpei;Kaufmann, Iena, V;Brecht, Michael
挠痒痒、感觉和笑之间的关系是复杂的。挠痒痒或仅仅是预期会让我们发笑，但当我们自己挠痒痒时就不会了。我们先前显示大鼠躯体感觉皮层驱动搔痒诱发的发声，现在研究自我搔痒抑制和搔痒预期。我们记录了挠痒痒和触摸大鼠以及大鼠触摸自己时的体感皮层活动。同种触摸和挠痒痒引起的躯体皮层兴奋和发声。自我触摸引起广泛的抑制和发声抑制。自我触摸也抑制发声和皮层反应引起的异体触摸或皮层微刺激。我们提出了一个自我挠痒痒抑制的全局抑制模型，它的运作没有经典假设的自我与他人的区别。与这种抑制假说相一致，用gabazine阻断皮层抑制消除了自我搔痒抑制。我们研究了一个用鼻子戳挠痒痒的范例中的预期。虽然老鼠的鼻子被挠痒痒，但它们也表现出逃跑，冻结和报警的声音。这种矛盾心理（“Nervenkitzel”）类似于儿童的挠痒痒行为。我们的结论是，自我触摸诱导的GABA能皮层抑制防止自我发痒，而预期的第5层活动驱动预期的笑声。
The relationship between tickling, sensation, and laughter is complex. Tickling or its mere anticipation makes us laugh, but not when we self-tickle. We previously showed rat somatosensory cortex drives tickling-evoked vocalizations and now investigated self-tickle suppression and tickle anticipation. We recorded somatosensory cortex activity while tickling and touching rats and while rats touched themselves. Allo-touch and tickling evoked somatotopic cortical excitation and vocalizations. Self-touch induced wide-ranging inhibition and vocalization suppression. Self-touch also suppressed vocalizations and cortical responses evoked by allo-touch or cortical microstimulation. We suggest a global-inhibition model of self-tickle suppression, which operates without the classically assumed self versus other distinction. Consistent with this inhibition hypothesis, blocking cortical inhibition with gabazine abolished self-tickle suppression. We studied anticipation in a nose-poke-for-tickling paradigm. Although rats nose poked for tickling, they also showed escaping, freezing, and alarm calls. Such ambivalence ("Nervenkitzel") resembles tickle behaviors in children. We conclude that self-touch-induced GABAergic cortical inhibition prevents self-tickle, whereas anticipatory layer 5 activity drives anticipatory laughter.