Modulation of epithelial innate immunity by autocrine production of nitric oxide
Modulation of epithelial innate immunity by autocrine production of nitric oxide
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DOI：
10.1016/j.ygcen.2008.09.012
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发表时间：
2009-05-15
影响因子：
2.7
通讯作者：
Dow, Julian A. T.
中科院分区：
文献类型：
--
作者：
Davies, Shireen-Anne;Dow, Julian A. T.
先天免疫机制，特别是与上皮组织相关的机制，是目前研究的重点，因为上皮免疫对健康和疾病有很大影响。然而，许多关于先天免疫信号通路在脊椎动物中的研究结果源于使用遗传模型Drosophilamelanogaster.Here的研究，我们讨论了在果蝇先天免疫上皮组织的核心重要性：通过自分泌产生的一氧化氮（NO）的IMD通路的调制;和整个动物的免疫功能的马氏（肾）小管的核心重要性。(C)2008年爱思唯尔公司All rights reserved.
Mechanisms of innate immunity especially with relevance to epithelial tissue, are currently the focus of intense research, as epithelial immunity greatly impacts on health and disease. However, many findings regarding innate immunity signalling pathways in vertebrates stems from research using the genetic model Drosophila melanogaster.Here we discuss the central importance of epithelial tissues in innate immunity in Drosophila: the modulation of the Imd pathway via autocrine production of nitric oxide (NO); and the central importance of the Malpighian (renal) tubule in immune function of the whole animal. (C) 2008 Elsevier Inc. All rights reserved.