Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?

Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?
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针对滑膜肉瘤中的铁死亡漏洞：一切都与 ME1 有关吗？

DOI：
10.1158/1078-0432.ccr-22-1257
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发表时间：
2022
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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通讯作者：
Gan,Boyi
Gan,Boyi
中科院分区：
--
文献类型：
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作者：
Subbiah,Vivek;Gan,Boyi

文献摘要

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了解代谢依赖性及其治疗弱点是精确肿瘤学的关键。苹果酸酶1（ME1）经常在癌症中过表达，具有促肿瘤发生作用。相比之下，与其他肉瘤相比，滑膜肉瘤中ME1表达的持续缺失表明在这种形式的癌症中精确治疗的独特铁凋亡倾向。第3573页
Understanding metabolic dependencies and their therapeutic vulnerabilities is key to precision oncology. Malic enzyme 1 (ME1) is frequently overexpressed in cancers with protumorigenic effects. In contrast, consistent loss of ME1 expression in synovial sarcoma compared with other sarcomas indicates a unique ferroptosis liability for precision therapy in this form of cancer.See related article by Brashears et al., p. 3573