Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor
Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor
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DOI：
10.1212/01.wnl.0000240130.94408.99
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发表时间：
2006-10-24
期刊：
影响因子：
9.9
通讯作者：
Deuschl, G.
中科院分区：
文献类型：
--
作者：
Daniels, C.;Peller, M.;Deuschl, G.
目的：研究特发性震颤（ET）患者的小脑灰质体积。方法：我们使用基于高分辨率 T1 加权 MRI 的基于体素的形态测量 (VBM) 来比较 27 名 ET 患者和 27 名年龄和性别匹配的健康对照受试者之间的灰质和白质密度。 14 名患者仅有姿势性震颤，而 13 名患者则表现出额外的意向性震颤。结果：VBM 未能证明 ET 患者灰质和白质体积的区域性减少。然而，根据震颤的类型，灰质会出现扩张。与年龄匹配的对照组相比，意向性震颤患者的颞顶交界区和右侧枕叶中皮质区域的双侧灰质相对扩张。结论：灰质和白质密度没有持续下降，这与特发性震颤中进行性神经退行性过程相矛盾，该过程导致小脑灰质体积大幅减少。以意向性震颤为主的患者表现出参与高阶视觉空间处理的灰质区域相对扩展，这可能代表了适应性重组的长期结果，补偿了颤抖情况下对熟练运动的视觉空间控制的更高要求。
Objective: To investigate cerebellar gray matter volume in patients with essential tremor (ET). Methods: We used voxel-based morphometry (VBM) based on high-resolution T1-weighted MRI to compare gray and white matter density between 27 patients with ET and 27 age- and sex-matched healthy control subjects. Fourteen patients had only postural tremor, whereas 13 patients showed additional intention tremor. Results: VBM failed to demonstrate regional decreases in gray and white matter volume in patients with ET. There was, however, an expansion in gray matter depending on the type of tremor. Compared with age- matched control groups, patients with intention tremor showed a relative expansion of gray matter bilaterally in the region of the temporoparietal junction and the right middle occipital cortex. Conclusions: The lack of a consistent decrease in gray and white matter density argues against a progressive neurodegenerative process in essential tremor that leads to a substantial decrease in cerebellar gray matter volume. Patients with predominant intention tremor show a relative expansion of gray matter areas involved in higher order visuospatial processing, which might represent a long-term result of adaptive reorganization compensating the higher demands on the visuospatial control of skilled movements in case of trembling.