IGFBP-2 is a negative predictor of cold-induced brown fat and bone young non-obese women
IGFBP-2 is a negative predictor of cold-induced brown fat and bone young non-obese women
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DOI：
10.1016/j.bone.2012.12.046
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发表时间：
2013-04-01
期刊：
影响因子：
4.1
通讯作者：
Klibanski, Anne
中科院分区：
文献类型：
--
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
最近的研究表明棕色脂肪组织（BAT）和骨矿物质密度（BMD）之间呈正相关。然而，这种关系背后的机制尚不清楚。胰岛素样生长因子1 (IGF-1) 是促进骨形成的干细胞分化的重要调节因子。 IGF 结合蛋白 2 (IGFBP-2) 与循环中的 IGF-1 结合，据报道可抑制人类骨形成。 IGF-1 也是棕色脂肪细胞分化的重要调节因子。我们假设 IGFBP-2 是 BAT 介导的成骨细胞生成的负调节剂，IGF-1 是正调节剂。因此，我们调查了 15 名女性（平均年龄 27.7 +/- 5.7 岁）的队列：5 名患有神经性厌食症 (AN)，其中 IGF-1 水平因饥饿而较低，5 名恢复了 AN (AN-R)，5 名体重正常。所有受试者均通过 PET/CT 评估冷激活 BAT，通过 DXA 评估脊柱、髋部、股骨颈和全身的 BMD，通过 MRI、IGF-1 和 IGFBP-2 评估大腿肌肉面积。 BAT 和 BMD 呈正相关，IGFBP-2 与 BAT 和 BMD 呈负相关。 IGF-1 和 BAT 之间没有关联。我们首次证明 IGFBP-2 是年轻非肥胖女性中寒冷诱导的 BAT 和 BMD 的负预测因子，这表明 IGFBP-2 可能作为 BAT 介导的成骨细胞生成的调节剂。 (C) 2013 Elsevier Inc. 保留所有权利。
Recent studies have shown a positive correlation between brown adipose tissue (BAT) and bone mineral density (BMD). However, mechanisms underlying this relationship are unknown. Insulin-like growth factor 1 (IGF-1) is an important regulator of stem cell differentiation promoting bone formation. IGF binding protein 2 (IGFBP-2) binds IGF-1 in the circulation and has been reported to inhibit bone formation in humans. IGF-1 is also a crucial regulator of brown adipocyte differentiation. We hypothesized that IGFBP-2 is a negative and IGF-1 a positive regulator of BAT-mediated osteoblastogenesis. We therefore investigated a cohort of 15 women (mean age 27.7 +/- 5.7 years): 5 with anorexia nervosa (AN) in whom IGF-1 levels were low due to starvation, 5 recovered AN (AN-R), and 5 women of normal weight. All subjects underwent assessment of cold-activated BAT by PET/CT, BMD of the spine, hip, femoral neck, and total body by DXA, thigh muscle area by MRI, IGF-1 and IGFBP-2. There was a positive correlation between BAT and BMD and an inverse association between IGFBP-2 and both BAT and BMD. There was no association between IGF-1 and BAT. We show for the first time that IGFBP-2 is a negative predictor of cold-induced BAT and BMD in young non-obese women, suggesting that IGFBP-2 may serve as a regulator of BAT-mediated osteoblastogenesis. (C) 2013 Elsevier Inc. All rights reserved.