Mitochondrial dysfunction-related genes in hepatocellular carcinoma
Mitochondrial dysfunction-related genes in hepatocellular carcinoma
复制标题
肝细胞癌线粒体功能障碍相关基因
DOI：
10.2741/4169
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发表时间：
2013-06-01
影响因子：
3.1
通讯作者：
Zheng, Shusen
中科院分区：
文献类型：
--
作者：
Wang, Weilin;Sun, Qiang;Zheng, Shusen
线粒体功能障碍与肿瘤细胞的凋亡抵抗和代谢有关。肝细胞癌（HCC）是一种复杂的异质性肿瘤，存在多种遗传变异.线粒体中的某些基因突变可能导致线粒体功能障碍。p53家族在线粒体凋亡途径中起着关键作用，并且是HCC中线粒体功能障碍的分子机制的一部分。在线粒体凋亡信号通路中发现的新基因，如mfn2，在p53网络中发挥作用。在线粒体代谢中，某些基因的表达可能与细胞凋亡有关，当它们参与肝癌发生时。MicroRNA也被发现在这一过程中发挥作用。一些基因甚至可能在HCC的线粒体功能障碍中表现出多种功能。在HCC治疗中，还发现基因通过细胞凋亡途径或自噬杀死细胞来影响化疗治疗。线粒体功能障碍相关基因的研究可能为靶向HCC的新疗法提供证据。
Mitochondria dysfunction is associated with apoptotic resistance and metabolism of tumor cells. Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations. Certain gene mutations in mitochondria may lead to mitochondrial dysfunction. The p53 family plays a key role in the mitochondrial apoptosis pathway and acts as part of the molecular mechanisms underlying mitochondrial dysfunction in HCC. The novel genes found in the mitochondrial apoptosis signaling pathways, such as mfn2, play a role in the p53 network. In mitochondrial metabolism, expression of certain genes may be associated with apoptosis when they are involved in hepatocarcinogenesis. MicroRNAs have also been found to play a role in this process. Some genes may even exhibit multiple functions in the mitochondrial dysfunction of HCC. In HCC therapy, genes have also been found to influence the chemotherapeutic treatment by killing cells via the apoptosis pathway or autophagy. Investigation of mitochondrial dysfunction-related genes could potentially provide evidence for novel therapies that target HCC.