TRANSCRIPTIONAL CONTROL BY E2F
TRANSCRIPTIONAL CONTROL BY E2F
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DOI：
10.1006/scbi.1995.0013
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发表时间：
1995-04-01
影响因子：
14.5
通讯作者：
KAELIN, WG
中科院分区：
文献类型：
--
作者：
ADAMS, PD;KAELIN, WG
大量证据表明，E2F/DRTF1转录因子家族(以下简称E2F)在细胞生长控制中起着关键作用。例如，几种小的DNA肿瘤病毒，如SV40，腺病毒和人乳头瘤病毒的转化能力一定。细胞与它们解除对E2F的调控的能力密切相关。此外，E2F似乎直接调节与DNA复制和细胞生长控制有关的一组不同基因的转录。最后，一些已知的细胞周期调节剂，其中一些在人类肿瘤中通常发生突变，似乎至少部分通过改变E2F活性来发挥作用。其中包括pRb、p53、cdk-2、cdk-4和某些细胞周期蛋白。
Considerable evidence suggests that the E2F/DRTF1 family Of transcription factors (hereafter referred to as 'E2F') plays a critical role in cell growth control. For example, the ability of several small DNA tumour viruses, such as SV40, adenovirus and human papillomavirus to transform certain. cells is tightly linked to their ability to deregulate E2F. Furthermore, E2F appears to directly regulate the transcription of a diverse set of genes implicated in DNA replication and cell growth control. Finally, a number of known cell cycle regulators, some of which are commonly mutated in human tumours, appear to exert their effects, at least in part, by altering E2F activity. Among these are pRb, p53, cdk-2, cdk-4 and certain cyclins.