LIMBIC-STRIATAL INTERACTIONS IN REWARD-RELATED PROCESSES
LIMBIC-STRIATAL INTERACTIONS IN REWARD-RELATED PROCESSES
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DOI：
10.1016/s0149-7634(89)80025-9
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发表时间：
1989-06-01
影响因子：
8.2
通讯作者：
EVERITT, BJ
中科院分区：
文献类型：
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作者：
ROBBINS, TW;CADOR, M;EVERITT, BJ
具有原动机中性特性的刺激从其与初级强化的预测关联中获得了激励特性，被称为条件强化。将间接多巴胺（DA）激动剂d-安非他明注入腹侧纹状体，选择性地增强了对光和水正相关的反应。这些选择性刺激作用被6-OHDA在腹侧纹状体的损伤所阻断，而不被背侧纹状体所阻断，与DA注入腹侧纹状体时产生的效果相似。然而，产生条件强化物的杠杆的选择不受腹侧纹状体DA消耗的影响。然而，这种选择被杏仁核基底外侧核的兴奋性毒性损伤削弱，这表明该结构与腹侧纹状体的da依赖过程之间存在相互作用，通过该过程，奖励相关的刺激会影响行为。使用二级性强化时间表获得了类似的结果。其他观察结果表明，杏仁核损伤不会损害奖励相关刺激的辨别特性，也不会影响主要动机。使用显性条件视觉空间辨别任务的实验表明，在腹侧纹状体（而非背侧纹状体）的DA耗竭后，类似的辨别特性得以保留。这些结果可能代表刺激-反应（或习惯）和刺激-奖励关联机制之间的分离，分别由背侧纹状体和腹侧纹状体调节。
Stimuli with formerly motivationally neutral properties gain incentive properties from their predictive association with primary reinforcement, and are termed conditioned reinforcers. Infusions of the indirect dopamine (DA) agonist d-amphetamine into the ventral striatum selectively enhanced responding for a light that was positively correlated with water. These selective stimulatory effects were blocked by 6-OHDA lesions of the ventral, but not dorsal striatum, and resembled those produced by DA itself when infused into the ventral striatum. However, the choice of the lever producing the conditioned reinforcer was not affected by ventral striatal DA depletion. This choice was, however, attenuated by excitotoxic lesions of the basolateral nucleus of the amygdala, suggesting an interaction between this structure and DA-dependent processes of the ventral striatum in the processes by which reward-related stimuli come to affect action. Parallel findings were obtained using a second order schedule of sexual reinforcement. Other observations indicated that the amygdala lesion did not impair the discriminative property of the reward-related stimuli, or affect primary motivation. Experiments using explicit conditional visuo-spatial discrimination tasks suggest that similar discriminative properties are preserved following DA depletion from the ventral, but not the dorsal, striatum. These results possibly represent a dissociation between stimulus-response (or habit) and stimulus-reward associative mechanisms, modulated respectively by the dorsal and ventral striatum.