Recent Advances in Understanding of NASH: MicroRNAs as Both Biochemical Markers and Players.
Recent Advances in Understanding of NASH: MicroRNAs as Both Biochemical Markers and Players.
复制标题
DOI：
10.1007/s40139-014-0049-8
复制
发表时间：
2014-09-01
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）正在成为美国和西方世界的主要肝病。人们正在做大量的工作来诊断、理解和探索这些多变量复杂疾病的发病机制。最近，一种新的生物调节途径正在探索中。MicroRNA是一种非编码RNA，可调节多种基因的表达，并与多种疾病有关。最近，越来越多的证据支持microRNA在NAFLD发病机制和NASH进展中的重要作用，并暗示它们可用作靶标、生物标志物和潜在的治疗工具。这篇综述旨在强调一些参与NAFLD和NASH发病机制的关键microRNA的最新工作。
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatis (NASH) are becoming the dominant liver diseases in the US and Western World. Extensive work is being done to diagnose, understand, and explore the pathogenesis of these multivariable complex diseases. Recently a new avenue of biologic regulation is being explored. MicroRNAs are non-coding RNAs that modulate the expression of multiple genes and have been implicated in multiple diseases. Recently there is a growing body of evidence supporting a significant role of microRNAs in NAFLD pathogenesis and progression to NASH, and hinting at their use as targets, biomarkers and potential therapeutic tools. This review is designed to highlight some of the recent work on a few of the key microRNAs involved in the pathogenesis of NAFLD and NASH.