Association of lifetime alcohol drinking trajectories with cardiometabolic risk
Association of lifetime alcohol drinking trajectories with cardiometabolic risk
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DOI：
10.1210/jc.2007-1395
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发表时间：
2008-01-01
影响因子：
5.8
通讯作者：
Trevisan, Maurizio
中科院分区：
文献类型：
--
作者：
Fan, Amy Z.;Russell, Marcia;Trevisan, Maurizio
背景和目的：饮酒者一生中酒精摄入量可能会有很大差异。本研究旨在检验终生饮酒轨迹是否与用于定义代谢综合征 (MetS) 的心血管危险因素相关。设计、设置、参与者和结果：这是一项基于人群的横断面研究。参与者是从纽约西部健康研究（1996-2001）的健康对照中选出的经常饮酒者（n = 2818），其中回顾性地确定了终生生活方式。主要结果是 MetS 及其各个组成部分的患病率，包括肥胖、高甘油三酯、低高密度脂蛋白胆固醇、高血压和高空腹血糖。 结果：轨迹分析基于 10 岁至 59 岁之间每个年龄十年的乙醇总公斤数的估计。获得了两组具有不同终生饮酒轨迹的饮酒者，即早期峰值组和稳定轨迹组。与稳定轨迹饮酒者相比，早期高峰饮酒者平均年轻 10 岁，较早开始定期饮酒，在青春期后期大量饮酒，在中年时逐渐减少，一生中平均每天饮酒更多，并且在接受采访时更有可能戒酒。在控制了年龄、性别和其他潜在混杂因素后，早期峰值轨迹与 MetS 的高几率有一定的相关性[1.31； 95% 置信区间 (CI) 1.00, 1.71] 总体而言，低高密度脂蛋白胆固醇 (1.62; 95% CI 1.27, 2.08)、腹部肥胖 (1.48; 95% CI 1.23, 1.78) 和超重 (1.32; 95% CI 1.10, 1.60)。青春期及早期大量饮酒 成年期可能与不良的心脏代谢特征有关。
Context and Objective: Alcohol intakes may vary considerably over a drinker's lifetime. This study was designed to examine whether lifetime drinking trajectories are associated with cardiovascular risk factors that are used to define the metabolic syndrome (MetS).Design, Setting, Participants, and Outcomes: This is a population-based cross-sectional study. Participants were ever-regular drinkers (n = 2818) selected from healthy controls for the Western New York Health Study (1996-2001) in which lifetime lifestyle was ascertained retrospectively. Prevalence of the MetS and its individual components, including obesity, high triglycerides, low high-density lipoprotein cholesterol, elevated blood pressure, and high fasting glucose, were the main outcomes.Results: Trajectory analyses were based on estimates of total kilograms of ethanol for each age decade between 10 and 59 yr. Two groups of drinkers with distinct lifetime drinking trajectories were obtained, an early peak and a stable trajectory group. Compared with stable trajectory drinkers, early-peak drinkers were 10 yr younger on average, had earlier onset of regular drinking, drank heavily in late adolescence and early adulthood tapering off in middle age, averaged more drinks per drinking day in lifetime, and were more likely to abstain when interviewed. After controlling for age, sex, and other potential confounders, early-peak trajectories were modestly associated with high odds of the MetS [1.31; 95% confidence interval (CI) 1.00, 1.71] overall, low high-density lipoprotein cholesterol (1.62; 95% CI 1.27, 2.08), abdominal obesity(1.48; 95% CI 1.23, 1.78), and overweight (1.32; 95% CI 1.10, 1.60).Conclusion: Early initiation of alcohol drinking and heavy drinking in adolescence and early adulthood may be associated with an adverse cardiometabolic profile.