Metabolism of platinum [14cethylenediamine dichloride in the rat
Metabolism of platinum [14cethylenediamine dichloride in the rat
复制标题
铂[14乙二胺二氯化物]在大鼠体内的代谢
DOI：
10.1016/0006-2952(73)90363-8
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发表时间：
1973
影响因子：
5.8
通讯作者：
A. Robins
中科院分区：
文献类型：
--
作者：
D. Taylor;Julie D. Jones;A. Robins
本文研究了Pt [14 C] enCl 2和195 mPt [14 C] enCl 2在正常和荷瘤大鼠组织中的分布，时间长达7天。药物在组织中的保留半衰期范围为2.5 - 7.6天。清除率在血清和肿瘤中最快，在肾脏、胰腺和肝脏中最慢。对Pt [14 C]en Cl 2在肝、肾和两种移植瘤中的亚细胞分布的研究表明，该药物主要以低分子量络合物的形式定位于细胞溶质中。发现肿瘤不同小区域中的药物浓度变化为2.7倍。14 C和195 mPt的分布在给予双标记药物后是相同的，这表明Pt乙二胺复合物在体内不解离。
The distribution of Pt [14C]ethylenediamine dichloride (Pt [14C]en Cl2) and195mPt([14C]en Cl2has been studied for a period of up to 7 days in the tissues of normal and tumour-bearing rats. The half-life of retention of the drug in the tissues ranged from 2.5 to 7.6 days. The rate of clearance was most rapid in the serum and tumour and slowest in kidney, pancreas and liver. Studies of the subcellular distribution of Pt [14C]en Cl2in liver, kidney and two transplanted tumours showed that the drug was localized mainly in the cytosol in the form of low molecular weight complexes. The concentration of the drug in different small areas of a tumour was found to vary by a factor of 2.7. The distribution of the14C and the195mPt was identical following administration of the doubly labelled drug suggesting that the Pt ethylenediamine complex does not dissociatein vivo.