Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase
Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase
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DOI：
10.1016/s0014-5793(04)00069-9
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发表时间：
2004-02-27
期刊：
影响因子：
3.5
通讯作者：
Kuechler, E
中科院分区：
文献类型：
--
作者：
Deszcz, L;Selpelt, J;Kuechler, E
多年来，基于多肽的氟甲基酮一直被认为是高度特异的caspase抑制剂，在许多系统中都能明显地阻断细胞凋亡的进程。在这里，我们证明了这些化合物可以显著减少鼻病毒在细胞培养中的复制。在它们的甲基化形式中，它们在体内和体外阻止eIF4GI裂解，并抑制微小核糖核酸病毒2A蛋白的活性(C)，2004年欧洲生化学会联合会。爱思唯尔出版，版权所有。
Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.