Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy
Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy
复制标题
DOI：
10.1159/000431331
复制
发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Hao, Chuan-Ming
中科院分区：
文献类型：
--
作者：
Xie, Qionghong;Li, Yan;Hao, Chuan-Ming
目的：探讨磷脂酶A2受体（PLA 2 R）在原发性和继发性膜性肾病（MN）中的表达。方法：收集经活检证实的MN和非MN患者。用抗PLA（2）R抗体（抗PLA（2）RAb）检测肾脏PLA（2）R，用间接免疫荧光法检测循环PLA（2）R-Ab。结果如下：在84%的特发性MN患者的毛细血管袢中检测到沿着肾PLA（2）R，而在其他原发性肾小球肾炎患者中未检测到PLA（2）R。38例狼疮性肾炎患者中仅1例肾组织PLA（2）R阳性。在B型肝炎病毒相关MN（HBV-MN）中，64%的患者肾组织PLA（2）R阳性，PLA（2）R与HBsAg沿着毛细血管袢重叠。此外，肾PLA（2）R阳性与血清PLA（2）R-Ab密切相关。血清PLA（2）R抗体阳性者肾组织PLA（2）R均阳性，血清PLA（2）R抗体阴性者肾组织PLA（2）R阳性率为53%。肾性PLA（2）R阴性者血清PLA（2）R-Ab均为阴性。结论：肾活检PLA（2）R阳性在特发性MN和HBV-MN中常见，而在狼疮相关性MN中少见，且与血清PLA（2）R-Ab的产生密切相关。进一步研究PLA（2）R与HBV-MN的关系可能有助于阐明特发性MN或HBV-MN的发病机制。(C)2015 S. Karger AG，巴塞尔
Objective: This study examined the expression of renal phospholipase A(2) receptor (PLA(2)R) in idiopathic and secondary membranous nephropathy (MN). Methods: Patients with biopsy-proven MN and non-MN were enrolled. Renal PLA(2)R was examined using an anti-PLA(2)R antibody (anti-PLA(2)RAb), and circulating PLA(2)R-Ab was detected by indirect immunofluorescence. Results: Renal PLA(2)R was detected along the capillary loop in 84% patients with idiopathic MN but not in those with any other primary glomerulonephritis. Only 1 of 38 patients with class V lupus nephritis showed renal PLA(2)R positive. In hepatitis B virus-associated MN (HBV-MN), 64% showed renal PLA(2)R positive, and PLA(2)R overlapped with HBsAg along the capillary loop. In addition, renal PLA(2)R positivity was closely associated with serum PLA(2)R-Ab. Renal PLA(2)R positive was present in all the patients with serum PLA(2)R-Ab positive and in 53% of patients with serum PLA(2)R-Ab negative. However, in patients with renal PLA(2)R negative, serum PLA(2)R-Ab was all negative. Conclusion: Renal biopsy PLA(2)R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA(2)R-Ab production. Further studies examining the association between PLA(2)R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN. (C) 2015 S. Karger AG, Basel