Rectal Cancer: Dynamic Contrast-Enhanced MRI Correlates With Lymph Node Status and Epidermal Growth Factor Receptor Expression
Rectal Cancer: Dynamic Contrast-Enhanced MRI Correlates With Lymph Node Status and Epidermal Growth Factor Receptor Expression
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DOI：
10.1002/jmri.24301
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发表时间：
2014-06-01
影响因子：
4.4
通讯作者：
Oberholzer, Katja
中科院分区：
文献类型：
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作者：
Lollert, Andre;Junginger, Theodor;Oberholzer, Katja
目的探讨直肠癌患者动态增强磁共振成像（DCE-MRI）与临床病理资料及血管生成表皮生长因子受体（EGFR）和CXC基序趋化因子受体4（CXCR 4）的关系。两个定量参数（k（21），A）来自药代动力学二室模型，和一个半定量参数（TTP）进行了评估。所有患者均行标准化手术和组织病理学检查。EGFR和CXCR 4的免疫组化染色进行了评价与一个标准化的scoringsystem.ResultsDCE-MRI参数A相关的N类（P = 0.048）和k（21）的发生同步和异时远处转移（P = 0.029）。k（21）和EGFR表达之间存在相关性（P = 0.107）。DCE-MRI参数TTP与EGFR表达之间存在显著相关性（P = 0.044）。结论DCE-MRI是一种无创性的检测直肠癌微循环的方法，且与EGFR表达相关。考虑到动态参数与临床病理数据之间的关系，DCE-MRI数据可能构成直肠癌患者淋巴结和远处转移的预后指标。J.磁共振Imaging 2014;39：1436-1442. (c)2013 Wiley Periodicals，Inc.
PurposeTo evaluate correlations between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinicopathologic data as well as immunostaining of the markers of angiogenesis epidermal growth factor receptor (EGFR) and CXC-motif chemokine receptor 4 (CXCR4) in patients with rectal cancer.Materials and MethodsPresurgical DCE-MRI was performed in 41 patients according to a standardized protocol. Two quantitative parameters (k(21), A) were derived from a pharmacokinetic two-compartment model, and one semiquantitative parameter (TTP) was assessed. Standardized surgery and histopathologic examinations were performed in all patients. Immunostaining for EGFR and CXCR4 was performed and evaluated with a standardized scoring system.ResultsDCE-MRI parameter A correlated significantly with the N category (P = 0.048) and k(21) with the occurrence of synchronous and metachronous distant metastases (P = 0.029). A trend was shown toward a correlation between k(21) and EGFR expression (P = 0.107). A significant correlation was found between DCE-MRI parameter TTP and the expression of EGFR (P = 0.044). DCE-MRI data did not correlate with CXCR4 expression.ConclusionDCE-MRI is a noninvasive method which can characterize microcirculation in rectal cancer and correlates with EGFR expression. Given the relationship between the dynamic parameters and the clinicopathologic data, DCE-MRI data may constitute a prognostic indicator for lymph node and distant metastases in patients with rectal cancer. J. Magn. Reson. Imaging 2014;39:1436-1442. (c) 2013 Wiley Periodicals, Inc.