Hormonal control of gene expression in the ovary.
Hormonal control of gene expression in the ovary.
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DOI：
10.1210/edrv-15-6-725
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发表时间：
1994-12
影响因子：
20.3
通讯作者：
J. Richards
中科院分区：
文献类型：
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作者：
J. Richards
卵泡的成熟包括几个连续的阶段：起始、生长、选择、排卵和黄体化（图1）。虽然启动“静止”原始卵泡生长的因子仍然难以捉摸，但控制哺乳动物卵泡生长的关键内分泌事件已经知道很多年了。例如，一旦卵泡开始生长，促性腺激素FSH和LH的基础浓度维持生长直到小窦期。通过促性腺激素基础浓度的微妙增加，如灵长类动物月经期（1）或啮齿类动物妊娠末期（2），选择小的有腔卵泡继续生长。一旦被选中，生长中的优势卵泡获得特定的功能特征，使其能够分化到排卵前阶段并合成雌二醇。血清雌二醇增加触发促性腺激素激增，反过来，刺激排卵前卵泡排卵和黄体化。
The maturation of ovarian follicles involves several sequential stages: initiation, growth, selection, ovulation, and luteinization (Fig. 1). Although the factor(s) that initiates the growth of “resting” primordial follicles remain elusive, the key endocrine events controlling follicular growth in mammals have been known for many years. For example, once follicles have begun to grow, basal concentrations of the gonadotropins, FSH and LH, maintain growth up until the small antral stage. Small antral follicles are selected to continue growth by subtle increases in basal concentrations of gonadotropins, such as those that occur at menses in primates (1) or at the end of pregnancy in rodents (2). Once selected, the growing dominant follicle(s) acquires specific functional characteristics that permit it to differentiate to the preovulatory stage and synthesize estradiol. Increased serum estradiol triggers the surge of gonadotropins that, in turn, stimulates the preovulatory follicle(s) to ovulate and luteinize...