Potential effects of adropin on systemic metabolic and hormonal abnormalities in polycystic ovary syndrome
Potential effects of adropin on systemic metabolic and hormonal abnormalities in polycystic ovary syndrome
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阿德罗平对多囊卵巢综合征全身代谢和激素异常的潜在影响
DOI：
10.1016/j.rbmo.2021.01.020
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发表时间：
2021-05-01
影响因子：
4
通讯作者：
Zhao, Yue
中科院分区：
文献类型：
--
作者：
Ye, Zhenhong;Zhang, Chunmei;Zhao, Yue
研究问题：本研究旨在探讨阿霉素对多囊卵巢综合征（PCOS）患者激素水平、糖脂代谢和氨基酸代谢的影响。结果：PCOS患者血浆和卵泡液中Adropin浓度均低于对照组（P < 0.001; P = 0.017），PCOS患者卵泡液中Adropin浓度高于对照组（P < 0.001; P = 0.017）。Adropin浓度与体重指数（BMI）、游离雄激素指数（FAI）、胰岛素抵抗指数（HOMA-IR）、雄烯二酮、甘油三酯呈负相关，与性激素结合球蛋白（SHBG）、高密度脂蛋白（HDL）呈正相关（均P < 0.05）。肥胖或糖耐量异常的PCOS患者肾上腺素浓度较低（P < 0.001）。PCOS组卵泡液Adropin浓度与HOMA-IR、异亮氨酸、缬氨酸呈负相关（均P < 0.05）。调整年龄、BMI、HOMA-IR和HDL后，SHBG仍显著影响血浆Adropin浓度（P = 0.022）。校正年龄和BMI后，阿霉素浓度降低的受试者患PCOS的几率仍然显著（P = 0.045）。SHBG调节后，血浆阿霉素与多囊卵巢综合征的相关性消失。结论：多囊卵巢综合征患者血浆和卵泡液中阿霉素浓度较低，可能影响胰岛素抵抗的发展。Adropin浓度与PCOS高雄激素血症之间的关系可能通过SHBG介导。阿霉素浓度降低与PCOS患者支链氨基酸代谢异常有关。
Research question: The study aimed to explore the effects of adropin on hormone concentrations and glucolipid and amino acid metabolism in patients with polycystic ovary syndrome (PCOS).Design: A total of 220 PCOS patients and 67 controls were recruited and basal state plasma was collected for adropin measurement. Follicular fluids from 50 PCOS patients and 30 controls were also collected for adropin analysis.Results: Plasma and follicular fluid adropin concentrations were lower in PCOS patients than controls (P < 0.001; P = 0.017). Adropin concentrations were negatively correlated with body mass index (BMI), free androgen index, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), androstenedione and triglycerides, and positively correlated with sex hormone-binding globulin (SHBG) and high-density lipoprotein (HDL) (all P < 0.05). PCOS patients who were either obese or glucose intolerant had lower adropin concentrations (P < 0.001). Follicular fluid adropin concentrations were negatively correlated with HOMA-IR, isoleucine and valine in the PCOS group (all P < 0.05). After adjusting for age, BMI, HOMA-IR and HDL, SHBG still significantly impacted the concentration of plasma adropin (P = 0.022). After adjusting for age and BMI, the odds of subjects with reduced adropin concentrations having PCOS still remained significant (P = 0.045). The association between plasma adropin and PCOS disappeared following SHBG adjustment.Conclusions: The concentrations of adropin in plasma and follicular fluid were lower in PCOS patients, which might affect the development of insulin resistance. The association between adropin concentrations and hyperandrogenaemia in PCOS might be mediated through SHBG. The decreased adropin concentrations are associated with abnormal branched-chain amino acid metabolism in PCOS.