Regulatory T cells dynamically control the primary immune response to foreign antigen
Regulatory T cells dynamically control the primary immune response to foreign antigen
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DOI：
10.4049/jimmunol.178.5.2961
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Chatila, Talal A.
中科院分区：
文献类型：
--
作者：
Haribhai, Dipica;Lin, Wen;Chatila, Talal A.
研究了使少量调节性T（T-R）细胞能够通过大得多的常规T细胞亚群控制对外源Ag的免疫应答的群体动力学。在初次免疫应答过程中，常规细胞和T-R细胞的扩增和收缩是同步发生的。重要的是，TR细胞在峰值响应时的相对积累显著超过常规T细胞的相对积累，反映了T-R细胞库内广泛的细胞分裂。在免疫前转移多克隆T-R细胞群体拮抗多克隆和TCR转基因应答，而阻断T-R细胞功能增强这些应答。这些结果定义了T-R和常规T细胞之间的反向定量关系，该关系控制初级免疫应答的大小。分裂的T-R细胞的高频率表明能够被广谱Ag激活的简并TCR特异性。
The population dynamics that enable a small number of regulatory T (T-R) cells to control the immune responses to foreign Ags by the much larger conventional T cell subset were investigated. During the primary immune response, the expansion and contraction of conventional and T-R cells occurred in synchrony. Importantly, the relative accumulation of TR cells at peak response significantly exceeded that of conventional T cells, reflecting extensive cell division within the T-R Cell pool. Transfer of a polyclonal T-R cell population before immunization antagonized both polyclonal and TCR transgenic responses, whereas blocking T-R cell function enhanced those responses. These results define an inverse quantitative relationship between T-R and conventional T cells that controls the magnitude of the primary immune response. The high frequency of dividing T-R cells suggests degenerate TCR specificity enabling activation by a broad spectrum of Ags.