Relation between insulin resistance and breast cancer among Chilean women
Relation between insulin resistance and breast cancer among Chilean women
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DOI：
10.1016/j.annepidem.2007.01.037
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发表时间：
2007-06-01
影响因子：
5.6
通讯作者：
Atalah, Eduardo
中科院分区：
文献类型：
--
作者：
Garmendia, Maria Luisa;Pereira, Ana;Atalah, Eduardo
目的：在智利，糖尿病和乳腺癌是重要的公共卫生问题。然而，胰岛素抵抗与乳腺癌之间的联系仍未得到很大程度的探讨。方法：我们在智利绝经前和绝经后妇女中进行了一项病例对照研究，以评估胰岛素抵抗(IR)与乳腺癌的关系。我们比较了170名年龄在33岁到86岁之间的乳腺癌女性和170名正常的乳房X光照相对照组，年龄间隔为5岁。测定血浆胰岛素和血糖，用稳态模型评估法计算胰岛素抵抗指数。还收集了人体测量以及社会人口学和行为数据。结果：IR与绝经后女性乳腺癌独立相关(OR=2.70，95%CI=1.10~6.63)，与绝经前女性乳腺癌无关(OR=0.84，95%CI=0.20~3.52)。肥胖与任何年龄的乳腺癌无关(OR=0.68，95%CI=0.39-1.20)。结论：在本样本中，IR增加了绝经后女性患乳腺癌的风险。
Purpose: In Chile, diabetes and breast cancer are important public health problems. The association between insulin resistance and breast cancer, however, remains largely unexplored.Methods: We conducted a case-control study to assess the relationship of insulin resistance (IR) and breast cancer in Chilean premenopausal and postmenopausal women. We compared 170 women, 33 to 86 years old, with incident breast cancer and 170 normal mammography controls, matched by 5-year age interval. Plasmatic insulin and glucose were measured and IR was calculated by the homeostasis model assessment method. Anthropometric measurements and sociodemographic and behavioral data were also collected. Odds ratios (ORs) and 95% confidence intervals (Cls) were estimated by multivariable conditional logistic regression.Results: IR was independently associated with breast cancer in postmenopausal women (OR = 2.70, 95%CI = 1.10-6.63), but not in premenopausal women (OR = 0.84, 95%CI = 0.20-3.52). Obesity was not associated with breast cancer at any age (OR = 0.68, 95%CI = 0.39-1.20).Conclusion: In this sample, IR increased the risk of breast cancer among postmenopausal women.