Dying to protect: cell death and the control of T-cell homeostasis.
Dying to protect: cell death and the control of T-cell homeostasis.
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DOI：
10.1111/imr.12538
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发表时间：
2017-05
影响因子：
8.7
通讯作者：
Hildeman DA
中科院分区：
文献类型：
--
作者：
Li KP;Shanmuganad S;Carroll K;Katz JD;Jordan MB;Hildeman DA
T细胞在免疫应答中发挥关键作用，因为它们特异性地识别肽/MHC复合物及其T细胞受体（TCRs）并启动适应性免疫应答。虽然T细胞对于执行适当的效应功能和维持免疫记忆至关重要，但如果它们被误导或失调，也会引起自身免疫或肿瘤。因此，T细胞从发育开始就必须受到严格的调控。维持适当的T细胞稳态对于促进保护性免疫和限制自身免疫和肿瘤形成至关重要。这篇综述将重点关注细胞死亡在维持T细胞稳态中的作用，并概述新的治疗策略，以控制细胞死亡来限制T细胞存活（如自身免疫和移植）或增强T细胞存活（如接种疫苗、免疫缺陷）。
T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T cell receptors (TCRs) and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions and maintaining immune memory, they also can cause autoimmunity or neoplasia if misdirected or dysregulated. Thus, T cells must be tightly regulated from their development onward. Maintenance of appropriate T cell homeostasis is essential to promote protective immunity and limit autoimmunity and neoplasia. This review will focus on the role of cell death in maintenance of T cell homeostasis and outline novel therapeutic strategies tailored to manipulate cell death to limit T cell survival (eg autoimmunity and transplantation) or enhance T cell survival (eg vaccination, immune-deficiency).