Modification of titanium alloys surface properties by plasma electrolytic oxidation (PEO) and influence on biological response
Modification of titanium alloys surface properties by plasma electrolytic oxidation (PEO) and influence on biological response
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DOI：
10.1007/s10856-017-5972-x
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发表时间：
2017-11-01
影响因子：
3.7
通讯作者：
Echeverria, Felix
中科院分区：
文献类型：
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作者：
Echeverry-Rendon, Monica;Galvis, Oscar;Echeverria, Felix
生物材料植入后，表面特征可以调节生物相互作用，改善或影响组织的整合。地形、润湿性、表面能和化学等特征可能是细胞和材料之间相互作用的关键决定因素。等离子体电解氧化(PEO)是一种通过在钛及其合金表面添加化学物种和产生不同形貌来控制这类参数的技术。为了提高生物响应性，用聚氧化乙烯(PEO)对C.P钛和Ti6Al4V进行了表面改性。通过对不同电解液、不同电压、不同电流密度和不同氧化时间的试验，得到了具有不同特性的表面。用X射线衍射仪(X射线衍射仪)、扫描电子显微镜(SEM)和辉光放电发射光谱仪(GDOES)等测试手段对所得材料进行了表征。测量了所得表面的润湿性，并计算了相应的表面能。除PEO外，无需任何其他处理即可获得接触角约为0度的超亲水表面，在某些情况下，这种条件在几周的阳极氧化后保持稳定；阳极表面的晶相组成(锐钛矿型-金红石型)似乎是获得这一性能的关键。最后，为了验证这些表面的生物效应，将成骨细胞种植在样品上。结果表明，随着表面自由能和涂层孔隙率的增加，电池行为得到改善，而粗糙度对电池行为的影响不明显。
Surface characteristics can mediate biological interaction improving or affecting the tissue integration after implantation of a biomaterial. Features such as topography, wettability, surface energy and chemistry can be key determinants for interactions between cells and materials. Plasma electrolytic oxidation (PEO) is a technique used to control this kind of parameters by the addition of chemical species and the production of different morphologies on the surfaces of titanium and its alloys. With the purpose to improve the biological response, surfaces of c.p titanium and Ti6Al4V were modified by using PEO. Different electrolytes, voltages, current densities and anodizing times were tested in order to obtain surfaces with different characteristics. The obtained materials were characterized by different techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM) and glow discharge optical emission spectroscopy (GDOES). Wettability of the obtained surfaces were measured and the corresponding surface energies were calculated. Superhydrophilic surfaces with contact angles of about 0 degrees were obtained without any other treatment but PEO and this condition in some cases remains stable after several weeks of anodizing; crystal phase composition (anatase-rutile) of the anodic surface appears to be critical for obtaining this property. Finally, in order to verify the biological effect of these surfaces, osteoblast were seeded on the samples. It was found that cell behavior improves as SFE (surface free energy) and coating porosity increases whereas it is affected negatively by roughness.