The COG database: a tool for genome-scale analysis of protein functions and evolution
The COG database: a tool for genome-scale analysis of protein functions and evolution
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DOI：
10.1093/nar/28.1.33
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发表时间：
2000-01-01
影响因子：
14.9
通讯作者：
Koonin, EV
中科院分区：
文献类型：
--
作者：
Tatusov, RL;Galperin, MY;Koonin, EV
蛋白质编码基因组的合理分类是使基因组序列最大限度地用于功能和进化研究的关键。蛋白质直链组簇（Clusters of Orthopathic Groups of Proteins，COG）数据库是对细菌、古细菌和真核生物21个完整基因组编码蛋白质进行系统分类的尝试（网址：//www.ncbi.nlm.nih.gov/COG),通过将基因组特异性最佳命中的一致性标准应用于来自这些基因组的所有蛋白质序列的详尽比较的结果来构建COG，该数据库包括2091个COG，其包括来自完整的细菌和古细菌基因组中的每一个的基因产物的56-83%，并且类似于来自酵母酿酒酵母基因组的那些的35%。COG数据库伴随着COGNITOR程序，该程序用于将新蛋白质拟合到COG中，并且可以应用于新测序的基因组的功能和系统发育注释。
Rational classification of proteins encoded sequenced genomes is critical for making the genome sequences maximally useful for functional and evolutionary studies, The database of Clusters of Orthologous Groups of proteins (COGs) is an attempt on a phylogenetic classification of the proteins encoded in 21 complete genomes of bacteria, archaea and eukaryotes (http://www.ncbi.nlm.nih.gov/COG), The COGs were constructed by applying the criterion of consistency of genome-specific best hits to the results of an exhaustive comparison of all protein sequences from these genomes, The database comprises 2091 COGs that include 56-83% of the gene products from each of the complete bacterial and archaeal genomes and similar to 35% of those from the yeast Saccharomyces cerevisiae genome. The COG database is accompanied by the COGNITOR program that is used to fit new proteins into the COGs and can be applied to functional and phylogenetic annotation of newly sequenced genomes.