INTRATHECAL SEROTONIN IN MICE - ANALGESIA AND INHIBITION OF A SPINAL ACTION OF SUBSTANCE-P
INTRATHECAL SEROTONIN IN MICE - ANALGESIA AND INHIBITION OF A SPINAL ACTION OF SUBSTANCE-P
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DOI：
10.1016/0024-3205(83)90785-3
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发表时间：
1983-01-01
期刊：
影响因子：
6.1
通讯作者：
WILCOX, GL
中科院分区：
文献类型：
--
作者：
HYLDEN, JLK;WILCOX, GL
小鼠鞘内注射5-羟色胺，在甩尾试验和皮下注射中产生剂量相关的镇痛作用。高渗盐水化验。低剂量(2.5-5 ng)的5-羟色胺可阻断鞘内P物质引起的咬合和抓挠反应。较高剂量的5-羟色胺本身会引起以后肢抓挠躯干为特征的行为综合征。5-羟色胺的镇痛反应和5-羟色胺引起的抓挠反应均被5-羟色胺拮抗剂阻断，其镇痛作用可能是通过对背角伤害性感觉神经元的突触后作用而实现的。
Serotonin, administered intrathecally in mice, produced dose-related analgesia in the tail flick test and the s.c. hypertonic saline assay. Low doses (2.5-5 ng) of serotonin blocked the biting and scratching response elicited by intrathecal substance P. Higher doses of serotonin itself elicited a behavioral syndrome characterized by scratching of the torso with the hindlimbs. Both the analgesic response and the scratching response due to serotonin were blocked by specific serotonin antagonists and the analgesia is likely mediated by a postsynaptic action on dorsal horn nociceptive neurons.