The Suppressor of Cytokine Signalling 3, SOCS3, may be One Critical Modulator of Seasonal Body Weight Changes in the Siberian Hamster, Phodopus sungorus
The Suppressor of Cytokine Signalling 3, SOCS3, may be One Critical Modulator of Seasonal Body Weight Changes in the Siberian Hamster, Phodopus sungorus
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DOI：
10.1111/j.1365-2826.2005.01394.x
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发表时间：
2006-02
影响因子：
3.2
通讯作者：
A. Tups;P. Barrett;A. Ross;Peter J. Morgan;Martin Klingenspor;Julian G. Mercer
中科院分区：
文献类型：
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作者：
A. Tups;P. Barrett;A. Ross;Peter J. Morgan;Martin Klingenspor;Julian G. Mercer
西伯利亚仓鼠，Phodopus sungorus，表现出显着的周期的体重，生殖和瘦素敏感性，在响应光周期的季节性变化。在本研究中，我们研究了细胞因子信号转导抑制因子3（SOCS 3）在调节季节性体重周期中起关键作用的假设。我们分析了弓状核SOCS 3基因表达在短日照（SD; 8：16 h光/暗）驯化西伯利亚仓鼠转移回长日照（LD; 16：8 h光/暗）和仓鼠自发成为photorefractory SD诱导的长期曝光。SD驯化仓鼠，转移回LD 1，2，3，4或6周，增加弓状核SOCS 3基因表达的LD水平在2周内，并保持这一较高的水平之后。SOCS 3基因表达的早期增加先于LD诱导的体重增加约3周。仓鼠在SD中保持较长时间（25周），开始变得对SD不敏感并增加体重。此时，尽管SD仓鼠的体重仍然受到抑制，但LD和SD光周期之间的SOCS 3基因表达水平没有差异。最后，通过比较西伯利亚仓鼠和叙利亚仓鼠，我们讨论了SOCS 3基因表达是否与SD诱导的性腺退化或体重下降有关。后者表现出显著的SD诱导的性腺退化，但体重的季节性变化有限。适应LD或SD 14周对SOCS 3基因表达没有影响。这意味着，弓状核SOCS 3基因的表达是不太可能与生殖活动的季节性周期。总之，这些发现进一步加强了我们的假设，即SOCS 3可能是体重季节性周期的一个分子触发因素。
The Siberian hamster, Phodopus sungorus, exhibits a remarkable cycle of body weight, reproduction and leptin sensitivity in response to a seasonal change in photoperiod. In the present study, we investigated the hypothesis that the suppressor of cytokine signalling 3 (SOCS3) plays a critical role in the regulation of the seasonal body weight cycle. We analysed arcuate nucleus SOCS3 gene expression in short day length (SD; 8 : 16 h light/dark) acclimated Siberian hamsters that were transferred back to long day length (LD; 16 : 8 h light/dark) and in hamsters that spontaneously became photorefractory to SD induced by prolonged exposure. SD acclimated hamsters that were transferred back to LD for 1, 2, 3, 4 or 6 weeks, increased arcuate nucleus SOCS3 gene expression to the LD level within 2 weeks, and maintained this higher level thereafter. The early increase of SOCS3 gene expression preceded the LD‐induced rise in body weight by approximately 3 weeks. Hamsters kept in SD for an extended period (25 weeks), began to become refractory to SD and to increase body weight. By this time, there was no difference in level of SOCS3 gene expression between LD and SD photoperiods, although body weight was still suppressed in SD hamsters. Finally, we addressed whether SOCS3 gene expression is related to SD‐induced gonadal regression or to body weight decrease by comparing Siberian hamsters with Syrian hamsters. The latter exhibited substantial SD‐induced gonadal regression but only limited seasonal changes in body weight. Acclimation to either LD or SD for 14 weeks had no effect on SOCS3 gene expression. This implies that arcuate nucleus SOCS3 gene expression is unlikely to be related to seasonal cycles in reproductive activity. Taken together, the findings further strengthen our hypothesis that SOCS3 may be one molecular trigger of seasonal cycles in body weight.