Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies
Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies
复制标题
DOI：
10.1007/s12185-023-03587-x
复制
发表时间：
2023-04-12
影响因子：
2.1
通讯作者：
Inoue, Daichi
中科院分区：
文献类型：
--
作者：
Hayashi, Yasutaka;Nishimura, Koutarou;Inoue, Daichi
造血是由一个称为生态位的骨髓特异性微环境维持和调节的。在血液系统恶性肿瘤中，肿瘤细胞诱导生态位重构，而重构的生态位与疾病发病密切相关。最近的研究表明，肿瘤细胞分泌的细胞外囊泡（EVs）在血液系统恶性肿瘤的生态位重塑中起主要作用。尽管ev正在成为潜在的治疗靶点，但其潜在的作用机制尚不清楚，选择性抑制仍然是一个挑战。本文综述了恶性血液病中骨髓微环境的重塑及其在发病机制中的作用，以及肿瘤源性ev的作用，并对该领域的未来研究进行了展望。
Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play a principal role in niche remodeling in hematological malignancies. Although EVs are emerging as potential therapeutic targets, the underlying mechanism of action remains unclear, and selective inhibition remains a challenge. This review summarizes remodeling of the bone marrow microenvironment in hematological malignancies and its contribution to pathogenesis, as well as roles of tumor-derived EVs, and provides a perspective on future research in this field.