Towards the total chemical synthesis of integral membrane proteins:: a general method for the synthesis of hydrophobic peptide-αthioester building blocks
Towards the total chemical synthesis of integral membrane proteins:: a general method for the synthesis of hydrophobic peptide-αthioester building blocks
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DOI：
10.1016/j.tetlet.2007.01.030
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发表时间：
2007-03-05
影响因子：
1.8
通讯作者：
Kent, Stephen B. H.
中科院分区：
文献类型：
--
作者：
Johnson, Erik C. B.;Kent, Stephen B. H.
Modification of a peptide-(alpha)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(alpha)thioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation. (c) 2007 Elsevier Ltd. All rights reserved.
