Layered MoS2 Hollow Spheres for Highly-Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors
Layered MoS2 Hollow Spheres for Highly-Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors
复制标题
层状MoS2空心球用于兔肝原位移植肿瘤的高效光热治疗
DOI：
10.1002/smll.201600191
复制
发表时间：
2016-04-20
期刊：
影响因子：
13.3
通讯作者：
Meng, Xianwei
中科院分区：
文献类型：
--
作者：
Tan, Longfei;Wang, Shengping;Meng, Xianwei
光热疗法（Photothermal Therapy，PTT）与临床技术相结合，克服肿瘤靶向性低、治疗效率低的缺点，具有巨大的基础和临床研究潜力。设计并制备了一种全新的MoS2纳米结构，通过简单快速的化学气溶胶流方法制备了在近红外区（NIR）具有强吸收和高光热转换效率的层状MoS2空心球（LMHS）。由于具有弯曲的层状空心球结构，所制备的LMHS与MoS2纳米片相比具有独特的电子性质。体外和体内研究表明，它们通过单次近红外光照射具有高的光热消融细胞和肿瘤消除率。系统急性毒性试验表明，这些LMHS对正常组织和血液的毒性可忽略不计。值得注意的是，首次引入微创介入技术来提高PTT药物的肿瘤靶向性。为探讨PTT对原位移植瘤的疗效，以新西兰白色兔肝VX 2肿瘤为动物模型。在数字减影血管造影、计算机断层扫描和热成像的指导下，PTT成功实现了肿瘤的有效消除，为肿瘤靶向输送和癌症治疗诊断应用提供了新的途径。
Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor therapy efficiency has great potential in basic and clinical researches. A brand-new MoS2 nanostructure is designed and fabricated, i.e., layered MoS2 hollow spheres (LMHSs) with strong absorption in near-infrared region (NIR) and high photothermal conversion efficiency via a simple and fast chemical aerosol flow method. Owing to curving layered hollow spherical structure, the as-prepared LMHSs exhibit unique electronic properties comparing with MoS2 nanosheets. In vitro and in vivo studies demonstrate their high photothermal ablation of cell and tumor elimination rate by single NIR light irradiation. Systematic acute toxicity study indicates that these LMHSs have negligible toxic effects to normal tissues and blood. Remarkably, minimally invasive interventional techniques are introduced to improve tumor targeting of PTT agents for the first time. To explore PTT efficiency on orthotopic transplantation tumors, New Zealand white rabbits with VX2 tumor in liver are used as animal models. The effective elimination of tumors is successfully realized by PTT under the guidance of digital subtraction angiography, computed tomography, and thermal imaging, which provides a new way for tumor-targeting delivery and cancer theranostic application.