Bone metabolism, vascular calcifications and mortality: associations beyond mere coincidence.
Bone metabolism, vascular calcifications and mortality: associations beyond mere coincidence.
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DOI：
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发表时间：
2005-07
影响因子：
3.4
通讯作者：
M. RodríguezGarcía;M. NavesDíaz;C. Jb
中科院分区：
文献类型：
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作者：
M. RodríguezGarcía;M. NavesDíaz;C. Jb
骨骼和心血管疾病是普通人群以及慢性肾脏疾病（CKD）患者常见的与年龄相关的疾病。最近的研究表明，这两种疾病与死亡率之间存在关联。本文讨论了CKD中骨质疏松概念的一些局限性，并比较了来自同一地理区域的非选择的普通人群和透析患者的骨骼和血管疾病和死亡率。在一般人群中，所有代谢紊乱以及血管钙化都随着年龄的增长而增加。血管钙化的进展与骨折的高患病率和发生率相关。此外，血管钙化和椎体骨折均与较高的死亡率相关。在透析患者中观察到类似的模式，椎体骨折没有增加，尽管血管钙化的患病率较高，两者也与较高的死亡率相关。年龄是与所有分析参数相关的最强变量，但在年龄调整后，一些关联仍然显著，这表明其他常见因素可能在骨骼和血管疾病的发病机制中发挥作用。
Bone and cardiovascular disorders are common age-related disorders in the general population and also in patients suffering from chronic kidney disease (CKD). Recent studies have shown an association between these two disorders and the rate of mortality. This article addresses some limitations of the concept of osteoporosis in CKD and compares bone and vascular disorders and mortality between non-selected general population and dialysis patients from the same geographic area. In the general population, all metabolic disorders increase with age, as well as vascular calcifications. The progression of vascular calcification was associated with a higher prevalence and incidence of bone fractures. In addition, both vascular calcifications and vertebral fractures were associated with higher mortality. A similar pattern was observed in dialysis patients with no increments in vertebral fractures, although with higher prevalence of vascular calcifications also both associated with higher mortality. Age was the strongest variable associated with all the analysed parameters, but some of the associations remained significant after age adjustment indicating the likely role of other common factors in the pathogenesis of bone and vascular disorders.