X-tra X: An escape to autoimmunity.
X-tra X: An escape to autoimmunity.
复制标题
X-tra X：逃避自身免疫。
DOI：
10.1172/jci130312
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Wu,GregoryF
中科院分区：
文献类型：
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作者：
Wu,GregoryF
确定导致多发性硬化症(MS)男性和女性疾病差异的因素对于破译免疫致病机制具有很大的希望。在本期JCI中，Itoh等人。利用实验性自身免疫性脑脊髓炎(EAE)模型，研究了Kdm6a基因的作用，Kdm6a是一种组蛋白去甲基酶基因，可逃脱X失活。在CD4+T细胞中的条件性基因敲除揭示了Kdm6a参与了一系列免疫过程，有可能使免疫偏向炎症反应。本研究简明地展示了X染色体基因表达在T细胞调节自身免疫中的价值，以及Kdm6作为MS模型在EAE发病机制中的相关性。
Identifying the factors driving disease disparities between males and females with multiple sclerosis (MS) holds great promise for deciphering immunopathogenic disease mechanisms. In this issue ofJCI, Itoh et al. explore the basis for sexual dimorphism in autoimmunity, specifically in MS. Using the experimental autoimmune encephalomyelitis (EAE) model of MS, which recapitulates CD4+T cell–dependent disease, the authors examined the contribution ofKdm6a,a histone demethylase gene known to escape X inactivation. Conditional knockout in CD4+T cells revealedKdm6ainvolvement with a collection of immunologic processes having the potential to skew immunity toward inflammatory responses. This study concisely shows the value of X chromosome gene expression in T cell regulation of autoimmunity and the relevance ofKdm6ain the pathogenesis of EAE as a model of MS.